| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Lust, Enn
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (8/8 displayed)
- 2024Exceptional Performance of Li-ion Battery Cells with Liquid Electrolyte at 100°Ccitations
- 2023Electrochemical Activation and NAP-XPS As Well As EIS Characterization of La0.31Sr0.58Ti0.97Ni0.03O3-δ Thin Film Electrode
- 2022Investigation of Oxygen Reduction on Platinum Nanoparticles Deposited Onto Peat-Derived Carbon Carrier
- 2021Carbide-Derived Carbons: WAXS and Raman Spectra for Detailed Structural Analysiscitations
- 2019Melt-electrospinning as a method to improve the dissolution and physical stability of a poorly water-soluble drugcitations
- 2018Low-temperature aging mechanisms of commercial graphite/LiFePO4 cells cycled with a simulated electric vehicle load profile—A post-mortem studycitations
- 2018Low-temperature aging mechanisms of commercial graphite/LiFePO 4 cells cycled with a simulated electric vehicle load profile—A post-mortem studycitations
- 2018Melt-electrospinning as a method to improve the dissolution and physical stability of a poorly water-soluble drugcitations
Places of action
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article
Melt-electrospinning as a method to improve the dissolution and physical stability of a poorly water-soluble drug
Abstract
<p>The present study introduces a modified melt-electrospinning (MES) method for fabricating the melt-electrospun fibers (MSFs) of a poorly water-soluble drug and carrier polymer. The MES of poorly water-soluble model drug indomethacin (IND) and hydrophilic carrier polymer, Soluplus (R) (SOL) were prepared at a 1:3 drug-polymer weight ratio. Water was used as an external plasticizer to regulate a MES processing temperature and to improve fiber formation. The fiber size, surface morphology, physical solid state, drug-polymer (carrier) interactions, thermal and chemical stability and dissolution behavior of MSFs were investigated. Solid state nuclear magnetic resonance spectroscopy (NMR) was used to measure T1(H-1), and the domain size of IND in MSFs (25-100 nm) was calculated from these results. Solid-state and thermal analysis confirmed the presence of amorphous solid dispersions of IND and SOL. IND was found to be chemically stable during an entire MES process. Only small drug content variability of different MSF batches was detected with high performace liquid chromatography (HPLC). Given findings were verified with the liquid NMR spectroscopy. The dissolution of MSFs was significantly faster than that of physical mixtures (PMs) or pure drug. The enhanced dissolution of MSFs was caused by high surface area, amorphous state of the drug and solubilizing properties of the carrier polymer (SOL).</p>