| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Almdal, Kristoffer
Technical University of Denmark
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (40/40 displayed)
- 2024In-situ mineralization of biomass-derived hydrogels boosts capacitive electrochemical energy storage in free-standing 3D carbon aerogelscitations
- 2024In-situ mineralization of biomass-derived hydrogels boosts capacitive electrochemical energy storage in free-standing 3D carbon aerogelscitations
- 2023Thin film and bulk morphology of PI-PS-PMMA miktoarm star terpolymers with both weakly and strongly segregated arm pairs
- 2022High Resolution Dual Material Stereolithography for Monolithic Microdevicescitations
- 2021Small-Angle Neutron Scattering Study of the Structural Relaxation of Elongationally Oriented, Moderately Stretched Three-Arm Star Polymerscitations
- 2020Stretch and orientational mode decoupling in relaxation of highly stretched polymer meltscitations
- 2020Stretch and orientational mode decoupling in relaxation of highly stretched polymer meltscitations
- 2019The amine:epoxide ratio at the interface of a glass fibre/epoxy matrix system and its influence on the interfacial shear strengthcitations
- 2018On the Morphological Behavior of ABC Miktoarm Stars Containing Poly(cis 1,4-isoprene), Poly(styrene), and Poly(2-vinylpyridine)citations
- 2017On the properties of poly(isoprene-b-ferrocenylmethyl methacrylate) block copolymerscitations
- 2017Mechanical properties of biaxially strained poly(L-lactide) tubes: Strain rate and temperature dependencecitations
- 2017Molecular weight-dependent degradation and drug release of surface-eroding poly(ethylene carbonate)citations
- 2016Characterization Of Biaxial Strain Of Poly(L-Lactide) Tubescitations
- 2015Microcantilever sensors for fast analysis of enzymatic degradation of poly (D, L-lactide)citations
- 2015Relaxation Mechanism and Molecular Structure Study of Polymer Blends by Rheological and SANS experiments
- 2015Transfer of Direct and Moiré Patterns by Reactive Ion Etching Through Ex Situ Fabricated Nanoporous Polymer Maskscitations
- 2015Entangled Polymer Melts in Extensional Flow - Characterization by Combined Rheology and Small-Angle Neutron Scattering
- 2015Entangled Polymer Melts in Extensional Flow - Characterization by Combined Rheology and Small-Angle Neutron Scattering
- 2014New approach of long-term modification of Topas® to acquire surface hydrophilicity for chromosome spreadingcitations
- 2014Micromechanical String Resonators: Analytical Tool for Thermal Characterization of Polymerscitations
- 2014Mechanical properties of electrospun PCL scaffold under in vitro and accelerated degradation conditionscitations
- 2013Preliminary characterization of glass fiber sizing
- 2013Concentrated Polymer Solutions are Different from Melts: Role of Entanglement Molecular Weightcitations
- 2013Process optimization of ultrasonic spray coating of polymer filmscitations
- 2012Are Entangled Polymer Melts Different From Solutions?
- 2012Are Entangled Polymer Melts Different From Solutions?
- 2012Process Optimization for Spray Coating of Poly (vinyl pyrrolidone)
- 2011Structure of PEP-PEO block copolymer micelles: Exploiting the complementarity of small-angle X-ray scattering and static light scatteringcitations
- 2011Shrinkage reduction of dental composites by addition of expandable zirconia fillercitations
- 2009Structural determination of ethylene-propylene-diene rubber (EPDM) containing high degree of controlled long-chain branchingcitations
- 2008ESC resistance of commercial grade polycarbonates during exposure to butter and related chemicalscitations
- 2007Plasma Polymerized Thin Films of Maleic Anhydride and 1,2-methylenedioxybenzene for Improving Adhesion to Carbon Surfacescitations
- 2007Hansen solubility parameters for a carbon fiber/epoxy compositecitations
- 2006An investigation on changes in chemical properties of pure ethylene-propylene-diene rubber in aqueous acidic environmentscitations
- 2002Miscibility evolution of polycarbonate/polystyrene blends during compoundingcitations
- 2002Effects of shear flow on a polymeric bicontinuous microemulsioncitations
- 2001Surface morphology of PS-PDMS diblock copolymer filmscitations
- 2001Conifer fibers as reinforcing materials for polypropylene-based compositescitations
- 2000Dynamic light scattering from ternary polymer blends
- 20003D-ising and Lifshitz critical behavior in a mixture of a polymer blend and a corresponding diblock copolymercitations
Places of action
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article
Molecular weight-dependent degradation and drug release of surface-eroding poly(ethylene carbonate)
Abstract
Poly(ethylene carbonate) (PEC) is a unique biomaterial showing significant potential for controlled drug delivery applications. The current study investigated the impact of the molecular weight on the biological performance of drug-loaded PEC films.<br/>Following the preparation and thorough physicochemical characterization of diverse PEC (molecular weights: 85, 110, 133, 174 and 196 kDa), the degradation and drug release behavior of rifampicin- and bovine serum albumin-loaded PEC films was investigated in vitro (in the presence and absence of cholesterol esterase), in cell culture (RAW264.7 macrophages) and in vivo (subcutaneous implantation in rats). All investigated samples degraded by means of surface erosion (mass loss, but constant molecular weight), which was accompanied by a predictable, erosion-controlled drug release pattern. Accordingly, the obtained in vitro degradation half-lives correlated well with the observed in vitro halftimes of drug delivery (R2 = 0.96). Here, the PEC of the highest molecular weight resulted in the fastest degradation/drug release. When incubated with macrophages or implanted in animals, the degradation rate of PEC films superimposed the results of in vitro incubations with cholesterol esterase. Interestingly, SEM analysis indicated a distinct surface erosion process for enzyme-, macrophage- and in vivo-treated polymer films in a molecular weight-dependent manner. <br/>Overall, the molecular weight of surface-eroding PEC was identified as an essential parameter to control the spatial and temporal on-demand degradation and drug release from the employed delivery system.