| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Paiva, Alexandre
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (45/45 displayed)
- 2024Exploring the biological properties and bioaccessibility of orange peel extracts using deep eutectic systemscitations
- 2023Using Natural Deep Eutectic Systems as Alternative Media for Ocular Applicationscitations
- 2023Alginate–Chitosan Membranes for the Encapsulation of Lavender Essential Oil and Development of Biomedical Applications Related to Wound Healingcitations
- 2023Hydrophobic DES Based on Menthol and Natural Organic Acids for Use in Antifouling Marine Coatingscitations
- 2023Uncovering biodegradability and biocompatibility of betaine-based deep eutectic systemscitations
- 2023Improving the activity of horseradish peroxidase in betaine-based natural deep eutectic systemscitations
- 2023Improving the activity of horseradish peroxidase in betaine-based natural deep eutectic systemscitations
- 2023Is it possible to correlate various physicochemical properties of Natural Deep eutectic systems in order to predict their behaviours as solvents?citations
- 2023Is it possible to correlate various physicochemical properties of Natural Deep eutectic systems in order to predict their behaviours as solvents?citations
- 2022Selective terpene based therapeutic deep eutectic systems against colorectal cancercitations
- 2022On the Not So Anomalous Water-induced Structural Transformations of Choline Chloride-Urea (Reline) Deep Eutectic Systemcitations
- 2022Fractionated extraction of polyphenols from mate tea leaves using a combination of hydrophobic/ hydrophilic NADEScitations
- 2022Fractionated extraction of polyphenols from mate tea leaves using a combination of hydrophobic/ hydrophilic NADEScitations
- 2022Subcritical Water as a Pre-Treatment of Mixed Microbial Biomass for the Extraction of Polyhydroxyalkanoatescitations
- 2022Subcritical Water as a Pre-Treatment of Mixed Microbial Biomass for the Extraction of Polyhydroxyalkanoatescitations
- 2022Assessing the Influence of Betaine-Based Natural Deep Eutectic Systems on Horseradish Peroxidasecitations
- 2022Assessment of deep eutectic solvents toxicity in zebrafish (Danio rerio)citations
- 2022Selective extraction and stabilization of bioactive compounds from rosemary leaves using a biphasic NADEScitations
- 2021Natural deep eutectic systems—A new era of cryopreservationcitations
- 2021Effect of water on the structure and dynamics of choline chloride/glycerol eutectic systemscitations
- 2021Evaluation of Deep Eutectic Systems as an Alternative to Solvents in Painting Conservationcitations
- 2021Deep eutectic systems from betaine and polyols – Physicochemical and toxicological propertiescitations
- 2021Improved storage of influenza HA-VLPs using a trehalose-glycerol natural deep eutectic solvent systemcitations
- 2021Unravelling the nature of citric acid:l-arginine:water mixtures ; The bifunctional role of watercitations
- 2021Low-Phytotoxic Deep Eutectic Systems as Alternative Extraction Media for the Recovery of Chitin from Brown Crab Shellscitations
- 2021Low-Phytotoxic Deep Eutectic Systems as Alternative Extraction Media for the Recovery of Chitin from Brown Crab Shellscitations
- 2021Influence of natural deep eutectic systems in water thermal behavior and their applications in cryopreservationcitations
- 2020Design and processing of drug delivery formulations of therapeutic deep eutectic systems for tuberculosiscitations
- 2020Terpene-Based Natural Deep Eutectic Systems as Efficient Solvents to Recover Astaxanthin from Brown Crab Shell Residuescitations
- 2019Unveil the Anticancer Potential of Limomene Based Therapeutic Deep Eutectic Solventscitations
- 2019Therapeutic Role of Deep Eutectic Solvents Based on Menthol and Saturated Fatty Acids on Wound Healingcitations
- 2018Synthesis and Physical and Thermodynamic Properties of Lactic Acid and Malic Acid-Based Natural Deep Eutectic Solventscitations
- 2018Natural deep eutectic systems as alternative nontoxic cryoprotective agentscitations
- 2017Production of Electrospun Fast-Dissolving Drug Delivery Systems with Therapeutic Eutectic Systems Encapsulated in Gelatincitations
- 2017A comparison between pure active pharmaceutical ingredients and therapeutic deep eutectic solventscitations
- 2017Green solvents for enhanced impregnation processes in biomedicinecitations
- 2017Production of electrospun fast-dissolving drug delivery systems with therapeutic eutectic systems encapsulated in gelatincitations
- 2017Stabilizing Unstable Amorphous Menthol through Inclusion in Mesoporous Silica Hostscitations
- 2016Solubility and Permeability Enhancement of active compounds: Therapeutic Deep Eutectic Systems as New Vehicles for Drug Deliverycitations
- 2016Dissolution enhancement of active pharmaceutical ingredients by therapeutic deep eutectic systemscitations
- 2015Design of controlled release systems for THEDES - Therapeutic deep eutectic solvents, using supercritical fluid technologycitations
- 2015Design of controlled release systems for THEDES - therapeutic deep eutectic solvents, using supercritical fluid technologycitations
- 2015Coupling Thedes - Therapeutic Deep Eutectic Solvents And Supercritical Fluid Technology for the Development of Controlled Delivery Systemscitations
- 2014Conversion of fat-containing waste from the margarine manufacturing process into bacterial polyhydroxyalkanoatescitations
- 2014Production of polyhydroxyalkanoates from spent coffee grounds oil obtained by supercritical fluid extraction technologycitations
Places of action
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article
A comparison between pure active pharmaceutical ingredients and therapeutic deep eutectic solvents
Abstract
<p>THEDES, so called therapeutic deep eutectic solvents are here defined as a mixture of two components, which at a particular molar composition become liquid at room temperature and in which one of them is an active pharmaceutical ingredient (API). In this work, THEDES based on menthol complexed with three different APIs, ibuprofen (ibu), BA (BA) and phenylacetic acid (PA), were prepared. The interactions between the components that constitute the THEDES were studied by NMR, confirming that the eutectic system is formed by H-bonds between menthol and the API. The mobility of the THEDES components was studied by PFGSE NMR spectroscopy. It was determined that the self-diffusion of the species followed the same behavior as observed previously for ionic liquids, in which the components migrate via jumping between voids in the suprastructure created by punctual thermal fluctuations. The solubility and permeability of the systems in an isotonic solution was evaluated and a comparison with the pure APIs was established through diffusion and permeability studies carried out in a Franz cell. The solubility of the APIs when in the THEDES system can be improved up to 12 fold, namely for the system containing ibu. Furthermore, for this system the permeability was calculated to be 14 × 10<sup>−5</sup> cm/s representing a 3 fold increase in comparison with the pure API. With the exception of the systems containing PA an increase in the solubility, coupled with an increase in permeability was observed. In this work, we hence demonstrate the efficiency of THEDES as a new formulation for the enhancement of the bioavailability of APIs by changing the physical state of the molecules from a solid dosage to a liquid system.</p>