Materials Map

Discover the materials research landscape. Find experts, partners, networks.

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The Materials Map is an open tool for improving networking and interdisciplinary exchange within materials research. It enables cross-database search for cooperation and network partners and discovering of the research landscape.

The dashboard provides detailed information about the selected scientist, e.g. publications. The dashboard can be filtered and shows the relationship to co-authors in different diagrams. In addition, a link is provided to find contact information.

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The Materials Map is still under development. In its current state, it is only based on one single data source and, thus, incomplete and contains duplicates. We are working on incorporating new open data sources like ORCID to improve the quality and the timeliness of our data. We will update Materials Map as soon as possible and kindly ask for your patience.

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Topics

Publications (62/62 displayed)

  • 2024Flexible Coatings Facilitate pH-Targeted Drug Release via Self-Unfolding Foils2citations
  • 2024Fully Biodegradable Elastomer-Based Device for Oral Macromolecule Delivery1citations
  • 20233D-printed Radiopaque Microdevices with Enhanced Mucoadhesive Geometry for Oral Drug Delivery10citations
  • 2022High-throughput 3d-printingcitations
  • 2022Self-propelled Janus micromotors for pH-responsive release of small molecule drug25citations
  • 2021Hot punching for loading of biodegradable microcontainers with budesonide-Soluplus film3citations
  • 2021The determinant role of fabrication technique in final characteristics of scaffolds for tissue engineering applications:A focus on silk fibroin-based scaffolds34citations
  • 2021Effects of chitosan/chondroitin sulfate polysaccharide lids on amoxicillin drug release from microcontainerscitations
  • 2021The determinant role of fabrication technique in final characteristics of scaffolds for tissue engineering applications34citations
  • 2019Artificial gut-on-a-disc platform to evaluate ph sensitive coatings of oral drug delivery devicescitations
  • 2019Fast and quantitative 2D and 3D orientation mapping using Raman microscopy53citations
  • 2019Where Is the Drug? Quantitative 3D Distribution Analyses of Confined Drug-Loaded Polymer Matrices6citations
  • 2019Thin Film Analysis by Nanomechanical Infrared Spectroscopy16citations
  • 2019Evaluation of the solid state form of tadalafil in sub-micron thin films using nanomechanical infrared spectroscopy6citations
  • 2019Thread-Like Radical-Polymerization via Autonomously Propelled (TRAP) Bots20citations
  • 2019Pyrolytic carbon resonators for micromechanical thermal analysis9citations
  • 2019Wafer-Scale Polymer-Based Transparent Nanocorals with Excellent Nanoplasmonic Photothermal Stability for High-Power and Superfast SERS Imaging17citations
  • 2018Using microcantilever sensors to measure poly(lactic-co-glycolic acid) plasticization by moisture uptake9citations
  • 2018Evaluation of the effects of spray drying parameters for producing cubosome powder precursors16citations
  • 2018Evaluation of the effects of spray drying parameters for producing cubosome powder precursors16citations
  • 2018Injection-Molded Microfluidic Device for SERS Sensing Using Embedded Au-Capped Polymer Nanocones44citations
  • 2017Microcontainers as an oral delivery system for spray dried cubosomes containing ovalbumin42citations
  • 2017Quantitative Detection of Trace Level Cloxacillin in Food Samples Using Magnetic Molecularly Imprinted Polymer Extraction and Surface-Enhanced Raman Spectroscopy Nanopillars86citations
  • 2016Microcontainers for Intestinal Drug Deliverycitations
  • 2016Wafer-Scale Nanopillars Derived from Block Copolymer Lithography for Surface-Enhanced Raman Spectroscopy40citations
  • 2016Supercritical impregnation of polymer matrices spatially confined in microcontainers for oral drug delivery: Effect of temperature, pressure and time29citations
  • 2016Synthesis and characterization of UV photocrosslinkable hydrogels with poly(N-vinyl-2-pyrrolidone): Determination of the network mesh size distribution14citations
  • 2016Triple co-culture cell model as an in vitro model for oral particulate vaccine systemscitations
  • 2016Nonlinear optomechanical measurement of mechanical motion124citations
  • 2015Fabrication of Ni stamp with high aspect ratio, two-leveled, cylindrical microstructures using dry etching and electroplating10citations
  • 2015Microcantilever sensors for fast analysis of enzymatic degradation of poly (D, L-lactide)6citations
  • 2015Fabrication and loading of oral drug delivery microcontainers using hot punchingcitations
  • 2015Hot punching of high-aspect-ratio 3D polymeric microstructures for drug delivery20citations
  • 2014Physical characterization of photocrosslinked poly(vinyl pyrrolidone) (PVP) hydrogels for drug deliverycitations
  • 2014Single-layer graphene on silicon nitride micromembrane resonators31citations
  • 2014Single-layer graphene on silicon nitride micromembrane resonators31citations
  • 2014Micromechanical String Resonators: Analytical Tool for Thermal Characterization of Polymers21citations
  • 2013Spray coating of microcontainers with eudragit using ferromagnetic shadow masks for controlled oral release of poorly water soluble drugs.citations
  • 2013Sensitive determination of the Young's modulus of thin films by polymeric microcantilevers15citations
  • 2013Plasma etching on large-area mono-, multi- and quasi-mono crystalline siliconcitations
  • 2013Plasma etching on large-area mono-, multi- and quasi-mono crystalline siliconcitations
  • 2013Biodegradable microcontainers as an oral drug delivery system for poorly soluble drugs.citations
  • 2013Ferromagnetic shadow mask for spray coating of polymer patterns13citations
  • 2013Process optimization of ultrasonic spray coating of polymer films100citations
  • 2013DNA hybridization sensing for cytogenetic analysiscitations
  • 2012Process Optimization for Spray Coating of Poly (vinyl pyrrolidone)citations
  • 2011Microwave absorption properties of gold nanoparticle doped polymers8citations
  • 2011Biodegradable micromechanical sensorscitations
  • 2011Fabrication and characterization of SRN/SU-8 bimorph cantilevers for temperature sensing18citations
  • 2010Double layer resist process scheme for metal lift-off with application in inductive heating of microstructures12citations
  • 2008Optimized plasma-deposited fluorocarbon coating for dry release and passivation of thin SU-8 cantilevers31citations
  • 2007Reliability of poly 3,4-ethylenedioxythiophene strain gauge24citations
  • 2007Single-mode waveguides with SU-8 polymer core and cladding for MOEMS applications104citations
  • 2005Investigation of the bond strength between the photo-sensitive polymer SU-8 and goldcitations
  • 2005Dry release of all-polymer structures35citations
  • 2005Highly Sensitive Polymer-based Cantilever-sensors for DNA Detection143citations
  • 2004Investigation of the bond strength between the photo-sensitive polymer SU-8 and Aucitations
  • 2003Polymeric mechanical sensors with strain gauge readout in a microfluidic systemcitations
  • 2003Polymeric cantilever arrays for biosensing applications72citations
  • 2003Polymeric Cantilever Arrays for Biosensing Applications72citations
  • 2003Optimised cantilever biosensor with piezoresistive read-out143citations
  • 2002Adsorption kinetics and mechanical properties of thiol-modified DNA-oligos on gold investigated by microcantilever sensors125citations

Places of action

Chart of shared publication
Krishnan, Samvrta
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Göncü, Nuray
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Vittorio, Laura De
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Ghavami, Mahdi
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Keller, Stephan Urs
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Tavanai, Hossein
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Okeyo, Peter Ouma
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Todeschini, Matteo
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Mortensen, Jacob
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Alves, Gustavo Marcati A.
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Rades, Thomas
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Thilsted, Anil H.
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Boyd, Ben
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Sun, Yi
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Li, Tao
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Taylor, Jacob M.
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Christensen, Claus Bo Vöge
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Co-Authors (by relevance)

  • Krishnan, Samvrta
  • Göncü, Nuray
  • Vittorio, Laura De
  • Milián-Guimerá, Carmen
  • Ghavami, Mahdi
  • Mccabe, Reece
  • Thamdrup, Lasse Højlund Eklund
  • Eklund Thamdrup, Lasse Højlund
  • Vila, Eduard Marzo
  • Hwu, Ente
  • Chang, Tien-Jen
  • Kjeldsen, Rolf Bech
  • Christfort, Juliane Fjelrad
  • Zór, Kinga
  • Nielsen, Line Hagner
  • Alstrøm, Tommy Sonne
  • Ilchenko, Oleksii
  • Atladóttir, Sylvía
  • Maric, Tijana
  • Keller, Stephan Urs
  • Abid, Zarmeena
  • Petersen, Ritika Singh
  • Andreoli, Francesca
  • Kristensen, Maja N.
  • Müllertz, Anette
  • Ajalloueian, Fatemeh
  • Khademolqorani, Sanaz
  • Chronakis, Ioannis S.
  • Tavanai, Hossein
  • Kamguyan, Khorshid
  • Ozaltin, Kadir
  • Guimera, Carmen Milian
  • Karakurt, Ilkay
  • Lehocky, Marian
  • Kinahan, David
  • Thoppe Rajendran, Sriram
  • Slipets, Roman
  • Okeyo, Peter Ouma
  • Bachmann, Florian
  • Pilgun, Yuriy
  • Kutsyk, Andrii
  • Poulsen, Henning, F.
  • Todeschini, Matteo
  • Mortensen, Jacob
  • Tentor, Fabio
  • Antalaki, Anastasia
  • Jacobsen, Rasmus D.
  • Mazzoni, Chiara
  • Ceccacci, Andrea Casci
  • Marizza, Paolo
  • Cagliani, Alberto
  • Schmid, Silvan
  • Bose-Goswami, Sanjukta
  • Afifi, Ahmad
  • Samaeifar, Fatemeh
  • Srivastava, Sarvesh Kumar
  • Larsen, Tom
  • Villanueva, Luis Guillermo
  • Larsen, Peter Emil
  • Nguyen, Long Quang
  • Rindzevicius, Tomas
  • Wu, Kaiyu
  • Mansano, Ronaldo D.
  • Alves, Gustavo Marcati A.
  • Bargholz, Mia Travers
  • Rades, Thomas
  • Von Halling Laier, Christoffer
  • Sjøltov, Pernille Bjerg
  • Laier, Christoffer Von Halling
  • Thilsted, Anil H.
  • Viehrig, Marlitt
  • Matteucci, Marco
  • Schmidt, Michael S.
  • Catak, Darmin
  • Boyd, Ben
  • Schmidt, Michael Stenbæk
  • Hansen, Mikkel Fougt
  • Sun, Yi
  • Ashley, Jon
  • Ndoni, Sokol
  • Schulte, Lars
  • Wang, Zhongli
  • Li, Tao
  • Pontoni, L.
  • Moneghini, M.
  • Kikic, I.
  • Zordi, N. De
  • Su, K.
  • Alopaeus, J. F.
  • Zeitler, J. A.
  • Solinas, D.
  • Cortesi, A.
  • Laurini, Erik
  • Goswami, Kaustav
  • Grassi, Mario
  • Posocco, Paola
  • Skov, Anne Ladegaard
  • Grassi, Gabriele
  • Abrami, Michela
  • Larobina, D.
  • Rossi, C. De
  • Boyd, B.
  • Lehr, C-M.
  • Rades, T.
  • Gordon, S.
  • Vanner, M. R.
  • Brawley, G. A.
  • Bowen, W. P.
  • Hansen, Ole
  • Bose, Sanjukta
  • Almdal, Kristoffer
  • Borre, Mads T.
  • Grassi, M.
  • Lapasin, R.
  • Grassi, G.
  • Abrami, M.
  • Marcus, Charles M.
  • Herring, Patrick K.
  • Polzik, Eugene S.
  • Shin, Yong Cheol
  • Usami, Koji
  • Sørensen, Anders S.
  • Kong, Jing
  • Armato, Bartolo
  • Taylor, Jacob M.
  • Zeuthen, Emil
  • Torrijo, Luis Guillermo Villanueva
  • Bagci, Tolga
  • Cassidy, Maja C.
  • Villanueva Torrijo, Luis Guillermo
  • Sommer-Larsen, Peter
  • Bergese, Paolo
  • Depero, Laura Eleonora
  • Federici, Stefania
  • Bontempi, Elza
  • Borgese, Laura
  • Colombi, Paolo
  • Davidsen, Rasmus Schmidt
  • Schmidt Davidsen, Rasmus
  • Nagstrup, Johan
  • Østergaard, Jesper
  • Gordon, Sarah
  • Bosco, Filippo
  • Dimaki, Maria
  • Svendsen, Winnie Edith
  • Brøgger, Anna Line
  • Dapra, Johannes
  • Kwasny, Dorota
  • Rozlosnik, Noemi
  • Tumer, Zeynep
  • Jakobsen, Mogens Havsteen
  • Johansen, Tom Keinicke
  • Jiang, Chenhui
  • Curri, M. L.
  • Ouattara, Lassana
  • Ingrosso, Chiara
  • Krozer, V.
  • Greve, Anders
  • Davis, Zachary James
  • Dohn, Søren
  • Knutzen, Michael
  • Hansen, M. F.
  • Häfliger, Daniel
  • Geschke, Oliver
  • Lillemose, Michael
  • Mateiu, Ramona Valentina
  • Hansen, Thomas Steen
  • Nordström, Maria
  • Zauner, Dan
  • Hübner, Jörg
  • Noguerón, E. Sánchez
  • Johansson, Alicia
  • Gomez, Montserrat
  • Clausen, Bjarne Hans
  • Haefliger, D.
  • Rasmussen, Peter Andreas
  • Nordstrøm, M.
  • Lechuga, L. M.
  • Tamayo, J.
  • Alvarez, M.
  • Sanches-Noguerón, E.
  • Clausen, B.
  • Nordstrom, Maria
  • Johansson, A.
  • Calleja, Montserrat
  • Rasmussen, P. A.
  • Lechuga, Laura M.
  • Tamayo De Miguel, Francisco Javier
  • Rasmussen, Peter
  • Calleja, M.
  • Lechuga, L.
  • Eriksen, S. C.
  • Thaysen, J.
  • Marie, Rodolphe Charly Willy
  • Christensen, Claus Bo Vöge
  • Jensenius, Henriette
  • Thaysen, Jacob
OrganizationsLocationPeople

article

Microcontainers as an oral delivery system for spray dried cubosomes containing ovalbumin

  • Boisen, Anja
  • Boyd, Ben
  • Rades, Thomas
  • Nielsen, Line Hagner
Abstract

The purpose of this study was to prepare cubosomes encapsulating the model antigen ovalbumin (OVA) via spray drying, and to characterise such cubosomes with a view for their potential application in oral vaccine delivery. Furthermore the cubosome formulation was loaded into polymeric microcontainers intended as an oral drug delivery system. The cubosomes consisted of commercial glyceryl monooleate, Dimodan®, containing OVA and were surrounded with a dextran shell prepared by spray drying. Cryo-TEM was used to confirm that cubosomes were formed after hydration of the spray dried precursor powder. The precursor powder had a mean particle size of 1.3±0.1μm, whereas the mean diameter of the dispersed cubosomes was 282±7nm (PDI: 0.18) measured by dynamic light scattering. 8.5±0.3% (w/w) of OVA was present in the cubosome powder and OVA was found released slowly over the first 70h, followed by a more rapid release. Total release of 47.9±2.8% of loaded OVA occurred over 96h in a buffer at pH 6.8. When the powder was filled into microcontainers, and the opening covered with the pH sensitive polymer Eudragit S100, the pH sensitive 'lid' was intact at gastric pH, but release of OVA from the cubosomes and microcontainers occurred at pH 6.8, releasing 44.1±5.6% of the OVA in 96h. Small-angle X-ray scattering (SAXS) revealed that the 'dry' particles possessed an internal ordered lipid structure (lamellar and inverse micellar phase) by virtue of a small amount of residual water, and after hydration in buffer at pH 6.8, the particles formed the hexagonal inverse cubic phases, thereby indicating that cubosomes were formed when released from microcontainers.

Topics
  • polymer
  • phase
  • transmission electron microscopy
  • drying
  • small angle x-ray scattering
  • dynamic light scattering