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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Kennedy, James E.
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (11/11 displayed)
- 2020The Effect of Various Nanoclay Surface Modifications on the Thermal and Mechanical Properties of Amorphous Polyamide Nanocomposites
- 2017Processing stability and the significance of variation in extrusion speeds and temperatures on SSB® 55 pharma grade shellac for oral drug deliverycitations
- 2017The development of a melt-extruded shellac carrier for the targeted delivery of probiotics to the coloncitations
- 2010Characterisation of the effects of a titanium micro particle filler on a polyether-block-amide host matrixcitations
- 2009Development and characterisation of an agar-polyvinyl alcohol blend hydrogelcitations
- 2008Characterisation and controlled drug release from novel drug-loaded hydrogelscitations
- 2007Preparation of monolithic matrices for oral drug delivery using a supercritical fluid assisted hot melt extrusion processcitations
- 2007The incorporation of an organically modified layered silicate in monolithic polymeric matrices produced using hot melt extrusioncitations
- 2007The synthesis, swelling behaviour and rheological properties of chemically crosslinked thermosensitive copolymers based on N-isopropylacrylamidecitations
- 2006The use of Agar as a novel filler for monolithic matrices produced using hot melt extrusioncitations
- 2006Lower critical solution temperature control and swelling behaviour of physically crosslinked thermosensitive copolymers based on N-isopropylacrylamidecitations
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article
The use of Agar as a novel filler for monolithic matrices produced using hot melt extrusion
Abstract
<p>The use of filler materials in an extended release monolithic polymer matrix can lead to a vastly altered release profile for the active pharmaceutical ingredient. A range of excipients for use in monolithic matrices have been discussed in the literature. The body of work described in this research paper outlines the use of agar as a novel filler material in a hot melt extruded polymer matrix. Several batches of matrix material were prepared with Diclofenac sodium used as the active pharmaceutical ingredient (API). Agar and microcrystalline cellulose were used as the filler materials in varying ratios, to examine the effect of % filler content as well as filler type on the properties of the hot melt extruded matrix. The resultant extrudates were characterised using steady state parallel plate rheometry, differential scanning calorimetry (DSC) and dissolution testing. The rheometry analysis concluded that the fillers used resulted in an increase in the matrix viscosity. The DSC scans obtained showed negligible effects on the melting behavior of the matrix as a result of the filler inclusion. Dissolution analysis showed that the presence of the fillers resulted in a slower release rate of API than for the matrix alone. The results detailed within this paper indicate that agar is a viable filler for extended release hot melt produced dosage forms.</p>