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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Massoud, Salah S.
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (22/22 displayed)
- 2023Dinuclear doubly bridged phenoxido copper(II) complexes as efficient anticancer agentscitations
- 2023Structure and magnetic characterization of some bicompartmental [N6O2] divalent metal(ii) complexes using bis(phenolato) ligands bearing two pendant bis(pyridyl) amine arms
- 2023Magnetostructural Properties of Some Doubly-Bridged Phenoxido Copper(II) Complexescitations
- 2023Copper(II) and zinc(II) complexes bridged by benzenoid aromatic oxocarbon and dicarboxylate dianionscitations
- 2021Synthesis, crystal structures, spectral, magnetic and thermal properties of 1-D polymeric dicyanamido-metal(II) complexescitations
- 2021Identification of potent anticancer copper(ii) complexes containing tripodal bis[2-ethyl-di(3,5-dialkyl-1H-pyrazol-1-yl)]amine moietycitations
- 2021Syntheses, structural characterization, and thermal behaviour of metal complexes with 3-aminopyridine as co-ligandscitations
- 2020Polynuclear and coordination polymers of copper(II) complexes assembled by flexible polyamines and bridging rigid N-heterocyclic multicarboxylatescitations
- 2019Azido-cobalt(II) coordination polymers exhibiting slow magnetic relaxation and metamagnetic transitioncitations
- 2019Structure, DFT Calculations, and Magnetic Characterization of Coordination Polymers of Bridged Dicyanamido-Metal(II) Complexescitations
- 2019Synthesis and characterization of 1D coordination polymers of metal(II)-dicyanamido complexescitations
- 2019Thiocyanato-metal(II) and azido-cobalt(III) complexes with hydroxymethylpyridinescitations
- 2017Synthesis, structural characterization and magnetic properties of polymeric azido Mn(II) complexes based on methyl-pyridine-N-oxide co-ligandscitations
- 2017Synthesis, crystal structures, spectral and magnetic properties of 1-D polymeric dicyanamido-metal(II) complexescitations
- 2017Pyridyl and triazole ligands directing the assembling of zinc(II) into coordination polymers with different dimensionality through azides.citations
- 2016Metal(II) complexes of compartmental polynuclear schiff bases containing phenolate and alkoxy groups.citations
- 2016Synthesis, characterization and luminescence properties of zinc(II) and cadmium(II) pseudohalide complexes derived from quinoline-N-oxide.citations
- 2015Magnetic and structural properties of dinuclear singly bridged-phenoxido metal(II) complexes.citations
- 2015Synthesis, characterization and luminescence properties of zinc(II) complexes of pseudohalides and nitrite derived from 4-azidopyridinecitations
- 2015Synthesis and characterization of three new 1-D polymeric [M2(4-azidopyridine)4(μ1,1-N3)2(μ1,3-N3)2]n (M = Ni, Co, Cd) complexes.citations
- 2015Five-coordinate metal(II) complexes based pyrazolyl ligands.citations
- 2015Synthesis and characterization of five new thiocyanato- and cyanato-metal(II) complexes with 4-azidopyridine as co-ligandcitations
Places of action
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article
Dinuclear doubly bridged phenoxido copper(II) complexes as efficient anticancer agents
Abstract
<p>Two cationic [Cu<sub>2</sub>(L<sup>1-2</sup>)<sub>2</sub>](ClO<sub>4</sub>)<sub>2</sub> (1, 2), and four neutral doubly bridged-phenoxido-copper(II) complexes [Cu<sub>2</sub>(L<sup>3-4</sup>)<sub>2</sub>] (3, 4) and [Cu<sub>2</sub>(L<sup>5-6</sup>)<sub>2</sub>(H<sub>2</sub>O)]‧2H<sub>2</sub>O (5, 6) as well as 1D polymeric catena-[Cu(L<sup>7</sup>)] (7), where HL<sup>1-2</sup> and H<sub>2</sub>L<sup>3-7</sup> represent tripodal tetradentate pyridyl or aliphatic-amino groups based 2,4-disubstituted phenolates, were synthesized and thoroughly characterized by various spectroscopic methods and single crystal X-ray analysis. The molecular structures of the complexes exhibited diverse geometrical environments around the central Cu(II) atoms. The in vitro antiproliferative activity of the isolated complexes and selected parent free ligands were screened against some human cancer cell lines (A2780, A2780R, PC-3, 22Rv1, MCF-7). The most promising cytotoxicity against cancer cells were obtained for 1–6, while complex 6 was found as the best performing as compared to the reference drug cisplatin. The cytotoxicity study of complex 6 was therefore extended to wider variety of cancer cell lines (HOS, A549, PANC-1, CaCo2, HeLa) and results revealed its significant cytotoxicity on all investigated human cancer cells. The cell uptake study showed that cytotoxicity of 6 (3 μM concentration and 24 h of incubation) against A2780 cells was almost independent from the intracellular levels of copper. The effect of complexes 4, 6 and 7 on cell cycle of A2780 cells indicates that the mechanism of action in these complexes is not only different from that of cisplatin but also different among them. Complex 7 was able to induce apoptosis in A2780 cells, while complexes 4 and 6 did not and on the other hand, they showed considerable effect on autophagy induction and there are some clues that these complexes were able to induce cuproptosis in A2780 cells.</p>