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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Michaux, Catherine
University of Namur
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (7/7 displayed)
- 2021Self-standing, conducting and capacitive biomimetic hybrid nanomembranes for selective molecular ion separationcitations
- 2018Properties of Omp2a-Based Supported Lipid Bilayerscitations
- 2016Electroassisted auto-assembly of alkylphosphonic acids monolayers on nitinolcitations
- 2015Polypyrrole-supported membrane proteins for bio-inspired ion channelscitations
- 2015Polypyrrole-supported membrane proteins for bio-inspired ion channelscitations
- 2012Stochastic simulation of structural properties of natively unfolded and denatured proteinscitations
- 2010Advantages of cocrystallization in the field of solid-statepharmaceutical chemistrycitations
Places of action
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article
Advantages of cocrystallization in the field of solid-statepharmaceutical chemistry
Abstract
<p>Cocrystallization (formation of a "cocrystal") is an emerging method to optimize physico-chemical properties of pharmaceutically active compounds. One elegant technique used to obtain such cocrystals is grinding the components together,either alone or in the presence of a small amount of solvent (so called solvent-drop grinding). Dry grinding has been used here to obtain cocrystals (actually a hydrated salt) of <sub>L</sub>-Proline and MnCl <sub>2</sub>. In that context,a new crystalline structure of a multicomponent molecular complex composed of <sub>L</sub>-Proline and MnCl<sub>2</sub> is here reported. The complex was characterized by powder and single-crystal X-ray diffraction and differential scanning calorimetry. This study underlines the interest of grinding as a method to synthesize original solid-state complexes. It also emphasizes the advantage of combining calorimetric and X-ray diffraction to characterize the newly formed solids. Finally,our work provides structural basis for the role that L-Proline can play within multicomponent solid-state molecular complexes,in particular as a potential cocrystal former acting by both ionic and H-bond interactions when combined to molecules of pharmaceutical interest.</p>