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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Janshoff, Andreas
University of Göttingen
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (9/9 displayed)
- 2019Vimentin Intermediate Filaments Undergo Irreversible Conformational Changes during Cyclic Loadingcitations
- 2015Actin filament turnover drives leading edge growth during myelin sheath formation in the central nervous system.citations
- 2014Biofunctionalization of Nanoporous Alumina Substrates
- 2011Separating Attoliter-Sized Compartments Using Fluid Pore-Spanning Lipid Bilayerscitations
- 2010Viscoelasticity of pore-spanning polymer membranes derived from giant polymersomescitations
- 2007Phase selection of calcium carbonate through the chirality of adsorbed amino acidscitations
- 2007Phasenselektion von Calciumcarbonat durch die Chiralität adsorbierter Aminosäurencitations
- 2004Quartz Crystal Microbalance for Bioanalytical Applications
- 2001Visualization of chemical and physical properties of calcium-induced domains in DPPC/DPPS Langmuir-Blodgett layerscitations
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article
Actin filament turnover drives leading edge growth during myelin sheath formation in the central nervous system.
Abstract
During CNS development, oligodendrocytes wrap their plasma membrane around axons to generate multilamellar myelin sheaths. To drive growth at the leading edge of myelin at the interface with the axon, mechanical forces are necessary, but the underlying mechanisms are not known. Using an interdisciplinary approach that combines morphological, genetic, and biophysical analyses, we identified a key role for actin filament network turnover in myelin growth. At the onset of myelin biogenesis, F-actin is redistributed to the leading edge, where its polymerization-based forces push out non-adhesive and motile protrusions. F-actin disassembly converts protrusions into sheets by reducing surface tension and in turn inducing membrane spreading and adhesion. We identified the actin depolymerizing factor ADF/cofilin1, which mediates high F-actin turnover rates, as an essential factor in this process. We propose that F-actin turnover is the driving force in myelin wrapping by regulating repetitive cycles of leading edge protrusion and spreading.