| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Fu, Y.
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (12/12 displayed)
- 2025Structural and electronic features enabling delocalized charge-carriers in CuSbSe 2citations
- 20233-Dimensional analysis of fatigue crack fields and crack growth by in situ synchrotron X-ray tomographycitations
- 2022Self healing of creep-induced damage in Fe-3Au-4W by multiple healing agents studied by synchrotron X-ray nano-tomographycitations
- 2022Combination of Knoevenagel polycondensation and water‐assisted dynamic Michael‐addition‐elimination for the synthesis of vinylene‐linked 2D covalent organic frameworkscitations
- 2020Efavirenz nanomicelles loaded vaginal film (EZ film) for preexposure prophylaxis (PrEP) of HIV.citations
- 2020Competitive Healing of Creep-Induced Damage in a Ternary Fe-3Au-4W Alloycitations
- 2017Large enhancement of the spin Hall effect in Au by scattering with side-jump on Ta impuritiescitations
- 2017Large enhancement of the spin Hall effect in Au by scattering with side-jump on Ta impuritiescitations
- 2015Interface engineering and characterization at the atomic-scale of pure and mixed ion layer gas reaction buffer layers in chalcopyrite thin-film solar cellscitations
- 2015Heterogeneous electrocatalysis in porous cathodes of solid oxide fuel cellscitations
- 2013CONTROL OF THE MORPHOLOGY OF PLA/PBAT/PA TERNARY BLENDS THROUGH THE USE OF A PBAT-B-PLA COPOLYMER
- 2012Toughness improvement of epoxy networks by nanophase-separating antiplasticizerscitations
Places of action
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article
Efavirenz nanomicelles loaded vaginal film (EZ film) for preexposure prophylaxis (PrEP) of HIV.
Abstract
Preexposure prophylaxis (PrEP) using oral or vaginal microbicide is an emerging and effective strategy to prevent HIV transmission. Vaginal film is becoming more acceptable and a convenient dosage form compared to cream, gel and suppository. Extremely poor aqueous solubility of efavirenz (EFV) limits its use as vaginal microbicide. The aim of this study was to develop and evaluate a monomeric surfactant free, rapidly soluble vaginal film of EFV (EZ film). EZ film was prepared using a tetrafunctional block polymer (Tetronic 1107), carrageenan and polyvinyl alcohol (PVA) by solvent evaporation method. First, different solubilizers were screened for EFV solubility, in vitro cytotoxicity and cell membrane integrity assay on HeLa cells. Optimized film was characterized for solid state, mechanical strength, epithelial integrity, in vitro drug release in simulated vaginal fluid (SVF), simulated seminal fluid (SSF) and in vitro anti-HIV activity. Optimized EZ film showed a particle size of 48 ± 3.8 nm with PDI of 0.299. Differential scanning colorimetry (DSC) thermogram suggested the complete amorphization of EFV within the film. EZ film rapidly disintegrated (30 s) with complete release of EFV in SVF and SSF. The film was found to be non-toxic to HeLa cells and showed similar anti-HIV-1 activity as that of EFV in DMSO. EZ film did not show any significant change in the TEER value in HEC 1A cell line. Hence, the findings from the current study strongly suggest that the EZ film could be a cost-effective and convenient dosage form for PrEP of HIV.