| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Proenca, Mp
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Topics
Publications (8/8 displayed)
- 2022Fabrication of FePt nanowires through pulsed electrodeposition into nanoporous alumina templatescitations
- 2017Tailoring Bi-Te based nanomaterials by electrodeposition: Morphology and crystalline structurecitations
- 2016Electrodeposition of ZnO thin films on conducting flexible substratescitations
- 2016Tuning the Stoichiometry of Ag2S Thin Films for Resistive Switching Applicationscitations
- 2015Study of magnetoelastic and magnetocrystalline anisotropies in CoxN1-x nanowire arrayscitations
- 2012pH sensitive silica nanotubes as rationally designed vehicles for NSAIDs deliverycitations
- 2011Tunning pore filling of anodic alumina templates by accurate control of the bottom barrier layer thicknesscitations
- 2010Cobalt ferrite thin films deposited by electrophoresis on p-doped Si substratescitations
Places of action
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article
pH sensitive silica nanotubes as rationally designed vehicles for NSAIDs delivery
Abstract
A novel pH-sensitive drug delivery system based on functionalized silica nanotubes was developed for the incorporation of non-steroidal anti-inflammatory drugs (NSAIDs), aimed at a tailored drug release in acidic conditions characteristic of inflamed tissues. Silica nanotubes (SNTs) were synthesized by a nanoporous alumina template assisted sol-gel method. Inner surfaces were physically and chemically modified to improve both the functionalization and subsequent incorporation of the drug. Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS) and transmission electron microscopy (TEM) were used to characterize the designed nanocarriers and their functionalization. To achieve the highest degree of functionalization, three types of aminosilanes were tested and calcination conditions were optimized. APTES was shown to be the most effective aminosilane regarding the functionalization of the SNTs' inner surface and an adequate calcination temperature (220 degrees C) was found to attain mechanical stability without compromising functionalization efficiency. Finally, the incorporation of naproxen into the nanotubes was accessed by fluorescence measurements and drug release studies were performed, revealing that the electrostatic linkage ensures effective release of the drug in the acidic pH typical of inflamed cells, while maintaining the SNT-drug conjugates stable at the typical bloodstream pH.