| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Mulet, Xavier
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (10/10 displayed)
- 2022Biomimetic Metal-Organic Frameworks as Protective Scaffolds for Live-virus Encapsulation and Vaccine Stabilisation – TEM Staining Considerations.
- 2022Biomimetic Metal-Organic Frameworks as Protective Scaffolds for Live-virus Encapsulation and Vaccine Stabilisation – TEM Staining Considerations.
- 2022Underlying Polar and Nonpolar Modification MOF-Based Factors that Influence Permanent Porosity in Porous Liquidscitations
- 2021Underlying solvent-based factors that influence permanent porosity in porous liquidscitations
- 2019Encapsulation, Visualization and Expression of Genes with Biomimetically Mineralized Zeolitic Imidazolate Framework-8 (ZIF-8)citations
- 2017Limitations with solvent exchange methods for synthesis of colloidalfullerenescitations
- 2013Predicting properties of nanoparticles for drug delivery and tissue targeting
- 2012Predicting phase behaviour of nanostructured lipid-based self-assembled materials
- 2012Predicting complex phase behaviour of self-assembling drug delivery nanoparticles
- 2011Robust and predictive modelling of amphiphilic nanostructured nanoparticle drug delivery vehicle phase behaviour
Places of action
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article
Limitations with solvent exchange methods for synthesis of colloidalfullerenes
Abstract
We have demonstrated that the use of tetrahydrofuran (THF) as a solvent to produce dispersed, water soluble fullerenes results in significant oxidation and degradation of the fullerene cage, which has not been reported previously. We also report a new finding that the use of N, N-dimethylformamide (DMF) can also generate stabilised fullerene (C60) nanoparticle dispersions in aqueous solutions including water and phosphate buffered saline (PBS) buffer. We compare this new DMF method with the well-known THF method following an extensive chemical and physical analysis of the resulting nanoparticles. The exact mechanism of action behind this oxidation and degradation is unknown, however, the role of peroxides is likely. The method of solvent exchange based on the use of DMF results in the formation of fullerene nanoparticle agglomerates that are highly stable in PBS and water, while the THF agglomerates are only stable in water. However, caution should be applied when using these approaches due to the significant degradation of the fullerene cage observed when using various techniques such as dynamic light scattering (DLS), matrix assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF), X-ray photoelectron spectroscopy (XPS), X-ray powder diffraction (XRD), fourier transform infrared spectroscopy (FTIR), proton nuclear magnetic resonance (1H NMR) and cryo transmission electron microscopy (cryo-TEM). Our results show that the solvent exchange technique using THF results in partial oxida-tion and degradation of C60, interestingly, the DMF evaporative method results in greater oxidation and degradation of C60 but significantly enhanced colloidal stability in buffer.