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Yun, F.
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Publications (3/3 displayed)
- 2009Common genetic variants of the vitamin D binding protein (DBP) predict differences in response of serum 25-hydroxyvitamin D [25(OH)D] to vitamin D supplementation.citations
- 2001Characterization of Inversion Domains in GaN by Electric Force Microscopy in conjunction with Transmission Electron Microscopy and Wet Chemical Etching
- 2000Characteristics of free-standing hydride-vapor-phase-epitaxy-grown GaN with very low defect concentrationcitations
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article
Common genetic variants of the vitamin D binding protein (DBP) predict differences in response of serum 25-hydroxyvitamin D [25(OH)D] to vitamin D supplementation.
Abstract
<h4>Background</h4>To determine the effect of vitamin D binding protein (DBP) genotypes on 25-hydroxyvitamin D [25(OH)D] changes with vitamin D supplements, we studied 98 adults receiving 600 or 4000 IU/d vitamin D(3) for one year.<h4>Methods</h4>The DBP functional variant, T436K, was genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).<h4>Results</h4>Mean 25(OH)D increases were 97% for TT (n=48), 151% for TK (n=31) and 307% (n=6) for KK genotypes (p=.004).<h4>Conclusions</h4>As with baseline 25(OH)D, T436K genotype predicts 25(OH)D changes after long-term vitamin D supplementation.