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| Naji, M. |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Petrov, R. H. | Madrid |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Postma, Almar
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Topics
Publications (9/9 displayed)
- 2023Exploiting NIR light mediated Surface-Initiated PhotoRAFT polymerization for orthogonal control polymer brushes and facile post-modification of complex architecture through opaque barrierscitations
- 2020Polymerized Ionic Liquid Block Copolymer Electrolytes for All-Solid-State Lithium-Metal Batteriescitations
- 2020Lipid Nanodiscs via Ordered Copolymerscitations
- 2018Optimisation of grafting of low fouling polymers from three-dimensional scaffoldscitations
- 2016Tannic Acid and Cholesterol-Dopamine as Building Blocks in Composite Coatings for Substrate-Mediated Drug Deliverycitations
- 2016Tannic Acid and Cholesterol-Dopamine as Building Blocks in Composite Coatings for Substrate-Mediated Drug Deliverycitations
- 2013Thermally cross-linkable copolymer and its evaluation as a hole transport layer in organic light-emitting diode devicescitations
- 2011Poly(vinyl alcohol) physical hydrogels: Noncryogenic stabilization allows nano- and microscale materials designcitations
- 2009Cholesterol-mediated anchoring of enzyme-loaded liposomes within disulfide-stabilized polymer carrier capsulescitations
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article
Lipid Nanodiscs via Ordered Copolymers
Abstract
A highly alternating copolymer composed of acrylic acid and styrene (AASTY) is synthesized with controlled radical polymerization by exploiting the reactivity ratios of the monomers to control the monomer sequence. The AASTY copolymers are effective solubilizers of cellular membranes and their embedded proteins,which improves structural characterization by single-particle cryo-electron microscopy (cryo-EM). These copolymers are promising tools for exploring detergent-free membrane protein solubilization and direct formation of native nanodiscs, facilitating structural and functional analysis of the mammalian proteome.