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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Hua, Y.
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (14/14 displayed)
- 2020Comparisons of corrosion behaviour for X65 and low Cr steels in high pressure CO2-saturated brine
- 2020Exogenous dihydrosphingosine 1 phosphate mediates collagen synthesis in cardiac fibroblasts through JAK/STAT signalling and regulation of TIMP1.citations
- 2019Localized and General Corrosion Characteristics of Carbon Steel in H2S Environments
- 2019Development and evaluation of miniature electrodes for electrochemical measurements in a CO₂ top of line corrosion environment
- 2019Development of an automated underwater abrasion rig to determine galvanic effects during the growth and localised breakdown of surface films in CO₂-containing solutions
- 2018Evaluation of high shear inhibitor performance in CO2-containing flow-induced corrosion and erosion-corrosion environments in the presence and absence of iron carbonate films
- 2018Corrosion Behaviour of X65 Steels in Water-Containing Supercritical CO₂ Environments With NO₂/O₂
- 2017Assessment of general and localized corrosion behavior of X65 and 13Cr steels in water-saturated supercritical CO2 environments with SO2/O2
- 2017Investigating pitting in X65 carbon steel using potentiostatic polarisation
- 2016Internal corrosion of carbon steel pipelines for dense phase CO₂ transport in Carbon Capture and Storage (CCS) - A reviewcitations
- 2015The effect of O2 content on the corrosion behavior of X65 and 5Cr in water-containing supercritical CO2 environmentscitations
- 2015The influence of SO₂ on the tolerable water content to avoid pipeline corrosion during the transportation of supercritical CO₂citations
- 2015Understanding the influence of SO2 and O2 on the Corrosion of Carbon Steel in Water-Saturated Supercritical CO2citations
- 2012Strain and lattice distortion in (1 1 0)-epitaxial orthorhombic TbMnO3 multiferroic thin films grown by pulsed laser depositioncitations
Places of action
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article
Exogenous dihydrosphingosine 1 phosphate mediates collagen synthesis in cardiac fibroblasts through JAK/STAT signalling and regulation of TIMP1.
Abstract
Cardiac fibrosis and myocyte hypertrophy are hallmarks of the cardiac remodelling process in cardiomyopathies such as heart failure (HF). Dyslipidemia or dysregulation of lipids contribute to HF. The dysregulation of high density lipoproteins (HDL) could lead to altered levels of other lipid metabolites that are bound to it such as sphingosine-1- phosphate (S1P). Recently, it has been shown that S1P and its analogue dihydrosphingosine-1-phosphate (dhS1P) are bound to HDL in plasma. The effects of dhS1P on cardiac cells have been obscure. In this study, we show that extracellular dhS1P is able to increase collagen synthesis in neonatal rat cardiac fibroblasts (NCFs) and cause hypertrophy of neonatal cardiac myocytes (NCMs). The janus kinase/signal transducer and activator (JAK/STAT) signalling pathway was involved in the increased collagen synthesis by dhS1P, through sustained increase of tissue inhibitor of matrix metalloproteinase 1 (TIMP1). Extracellular dhS1P increased phosphorylation levels of STAT1 and STAT3 proteins, also caused an early increase in gene expression of transforming growth factor-β (TGFβ), and sustained increase in TIMP1. Inhibition of JAKs led to inhibition of TIMP1 and TGFβ gene and protein expression. We also show that dhS1P is able to cause NCM hypertrophy through S1P-receptor-1 (S1PR1) signalling which is opposite to that of its analogue, S1P. Taken together, our results show that dhS1P increases collagen synthesis in cardiac fibroblasts causing fibrosis through dhS1P-JAK/STAT-TIMP1 signalling.