| People | Locations | Statistics |
|---|---|---|
| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Bernaerts, Katrien
Maastricht University
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (14/14 displayed)
- 2023Investigation of monomer reactivity, polymer microstructure and solubility in the copolymerization of 1,5-dioxepan-2-one with alkyl substituted lactonescitations
- 2022Condensation Polyesterscitations
- 2022Additive Manufacturing of α-Amino Acid Based Poly(ester amide)s for Biomedical Applicationscitations
- 2022The effect of carbon fiber content on physico-mechanical properties of recycled poly(ethylene terephthalate) composites additively manufactured with fused filament fabricationcitations
- 2021Shaping and properties of thermoplastic scaffolds in tissue regeneration: The effect of thermal history on polymer crystallization, surface characteristics and cell fatecitations
- 2021Development of marine oligosaccharides for potential wound healing biomaterials engineeringcitations
- 2021Post-Modification of Biobased Pyrazines and Their Polyesterscitations
- 2021The effect of copolymerization of cyclic dioxolane moieties on polyamide propertiescitations
- 2020Biobased Pyrazine-Containing Polyesterscitations
- 2018Synthesis of isotactic polypropylene-block-polystyrene block copolymers as compatibilizers for isotactic polypropylene/polyphenylene oxide blendscitations
- 2017Increasing the solubility range of polyesters by tuning their microstructure with co-monomers
- 2017Increasing the solubility range of polyesters by tuning their microstructure with co-monomers
- 2017Increasing the solubility range of polyesters by tuning their microstructure with comonomerscitations
- 2017Increasing the solubility range of polyesters by tuning their microstructure with comonomerscitations
Places of action
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article
Development of marine oligosaccharides for potential wound healing biomaterials engineering
Abstract
This study aims to investigate the oxidative degradation of chitosan to produce chitooligosaccharides (CHOS) as a potential bioagent for biomaterials engineering. CHOS was produced via microwaved-assisted oxidative degradation of chitosan by using hydrogen peroxide in an acidic aqueous solution. The effects of the H2O2 concentration, reaction time, microwave power, and reaction temperature on the degradation of chitosan were investigated. Following optimization of these parameters, three soluble CHOS fractions CHOS 1 (4-8 kDa), CHOS 2 (3-5 kDa), and CHOS 3 (1-3 kDa) were synthesized and the physicochemical, structural, thermal properties and water solubility were investigated. No significant structure alteration of the initial chitosan was detected by Fourier transform infrared spectroscopy (FTIR), UV–vis, and nuclear magnetic resonance (NMR) analyses, making our microwave-assisted oxidative degradation a valuable method for the production of CHOS. Interestingly, CHOS fractions exhibited improved radical scavenging activities and antibacterial activities compared to the initial chitosan. The half maximal effective concentration (EC50) of the CHOS fractions were found to be in the range of 2.69–0.724 mg/mL significantly lower than the chitosan (7.75, mg/mL). Besides, the CHOS fractions exhibited lower minimum inhibitory concentration (MIC; in the range of 62.5–500 µg/mL) compared to the initial chitosan (>1000 µg/mL). Moreover, the 3T3-Ll fibroblast cells treated with CHOS fractions exhibited more than 95% viability after 48 h of culture. Cell migration and collagen production assays also showed the positive effect of CHOS fractions, particularly CHOS 3. These results indicate that CHOS can be a promising bioactive agent in biomedical applications, in particular for wound healing applications.