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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Fonseca, I. M.
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (9/9 displayed)
- 2024Natural polymers, silica, and carbon-based aerogels
- 2023P-Doped carbon catalyst highly efficient for benzodiazepine synthesiscitations
- 2021How Molecular Mobility, Physical State, and Drug Distribution Influence the Naproxen Release Profile from Different Mesoporous Silica Matricescitations
- 2020Free-standing N-Graphene as conductive matrix for Ni(OH)2 based supercapacitive electrodescitations
- 2017Stabilizing Unstable Amorphous Menthol through Inclusion in Mesoporous Silica Hostscitations
- 2016Accessing the Physical State and Molecular Mobility of Naproxen Confined to Nanoporous Silica Matrixescitations
- 2014Influence of nanoscale confinement on the molecular mobility of ibuprofencitations
- 2014Influence of nanoscale confinement on the molecular mobility of ibuprofencitations
- 2013Photoinduced reactions occurring on activated carbons. A combined photooxidation and ESR studycitations
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article
P-Doped carbon catalyst highly efficient for benzodiazepine synthesis
Abstract
<p>Carbon catalysts prepared from pyrolysis of spent tires are found to efficiently catalyse the synthesis of benzodiazepine 1, from o-phenylendiamine 2 and acetone 3, with high conversions and selectivity, under mild reaction conditions, according to Scheme 1. The most acidic catalyst, CPN_H<sub>3</sub>PO<sub>4</sub>, obtained by chemical activation with H<sub>3</sub>PO<sub>4</sub>, resulted on the most efficient catalyst affording conversion values higher than 90 %, after 4 h of reaction time, and selectively leading to benzodiazepine 1 (90 %). On the other hand, the CPN and CPN_CO<sub>2</sub> catalysts reached high conversions of 2 although diminished selectivity to 1, confirming that the carbon matrix is involved in the first steps of the reaction mainly catalyzing the formation of intermediate 4 as the main reaction product. Note that all the investigated catalysts are macroporous materials with pore size distribution large enough to favor diffusion of reactants and products. Therefore, the catalytic performance is mainly governed by the chemical surface, in particular by the presence of acid functions as phosphate groups anchored to the carbon surface or as SiP<sub>2</sub>O<sub>7</sub> supported phase. Finally, considering both experimental and theoretical results, it seems that the most probable catalytic centers comprise phosphate functions in SiP<sub>2</sub>O<sub>7</sub> catalyzing the last cyclization step to 1. Although electrophilicity of carbon acceptor (C[dbnd]N moiety) in the presence of model simulating phosphate groups anchored to the carbon surface was slightly superior, transition structure in the presence of model simulating SiP<sub>2</sub>O<sub>7</sub> showed the smallest free energy barrier.</p>