| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Laity, Peter
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Publications (5/5 displayed)
- 2022Iron oxide and water paste rheology and its effect on low adhesion in the wheel/rail interfacecitations
- 2020Thermodynamics of clay – Drug complex dispersionscitations
- 2020A molecular understanding of magnesium aluminium silicate – drug, drug - polymer, magnesium aluminium silicate - polymer nanocomposite complex interactions in modulating drug releasecitations
- 2020Use of thermodynamics in understanding drug release from xanthan gum matricescitations
- 2019Real time calorimetric characterisation of clay–drug complex dispersions and particlescitations
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article
Use of thermodynamics in understanding drug release from xanthan gum matrices
Abstract
The aim of this study was to outline a novel way of understanding the controlled drug release from drug-clay-polymer matrices using isothermal calorimetry (ITC) as a complementary technique to dissolution studies. ITC results showed that the binding phenomenon between the model drug propranolol hydrochloride (PPN) and magnesium aluminium silicate (MAS) in the presence of xanthan gum (XG was spontaneous and enthalpically driven (negative enthalpy (ΔH) and small entropy (-T∆S)). This may be due to the competition for PPN due to the anionic nature of XG. Dissolution results showed that when using the MAS-PPN complexes, 10 % w/w XG polymer level was enough to significantly reduce the burst release. When used together, ITC and dissolution studies may help a formulator understand and identify interactions which occur during dissolution studies and may be beneficial to the controlled drug delivery system.