| People | Locations | Statistics |
|---|---|---|
| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Danti, Serena
University of Pisa
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (12/12 displayed)
- 20243D Printed Piezoelectric BaTiO3/Polyhydroxybutyrate Nanocomposite Scaffolds for Bone Tissue Engineeringcitations
- 2023Characterization of Cyclic Olefin Copolymers for Insulin Reservoir in an Artificial Pancreascitations
- 2023Chitin nanofibrils modulate mechanical response in tympanic membrane replacementscitations
- 2023Recent developments in nanocellulose-based aerogels as air filters: A reviewcitations
- 2023A Straightforward Method to Produce Multi-Nanodrug Delivery Systems for Transdermal/Tympanic Patches Using Electrospinning and Electrospraycitations
- 2022Local Piezoelectric Response of Polymer/Ceramic Nanocomposite Fiberscitations
- 2020Overview of Agro-Food Waste and by Products Valorization for Polymer Synthesis, and Modification for Bio-Composite Production.
- 2019Surface Modified Nanostructured Piezoelectric Device as Cost-Effective Transducer for Energy and Biomedicinecitations
- 2014Interfacing polymeric scaffolds with primary pancreatic ductal adenocarcinoma cells to develop 3D cancer modelscitations
- 2010Preparation of stable dispersion of barium titanate nanoparticles: Potential applications in biomedicinecitations
- 2010Barium Titanate Nanoparticles: Highly Cytocompatible Dispersions in Glycol-chitosan and Doxorubicin Complexes for Cancer Therapy.citations
- 2010Barium Titanate Nanoparticles: Highly Cytocompatible Dispersions in Glycol-chitosan and Doxorubicin Complexes for Cancer Therapycitations
Places of action
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article
Chitin nanofibrils modulate mechanical response in tympanic membrane replacements
Abstract
The tympanic membrane (TM), is a thin tissue lying at the intersection of the outer and the middle ear. TM perforations caused by traumas and infections often result in a conductive hearing loss. Tissue engineering has emerged as a promising approach for reconstructing the damaged TM by replicating the native material characteristics. In this regard, chitin nanofibrils (CN), a polysaccharide-derived nanomaterial, is known to exhibit excellent biocompatibility, immunomodulation and antimicrobial activity, thereby imparting essential qualities for an optimal TM regeneration. This work investigates the application of CN as a nanofiller for poly(ethylene oxide terephthalate)/poly(butylene terephthalate) (PEOT/PBT) copolymer to manufacture clinically suitable TM scaffolds using electrospinning and fused deposition modelling. The inclusion of CN within the PEOT/PBT matrix showed a three-fold reduction in the corresponding electrospun fiber diameters and demonstrated a significant improvement in the mechanical properties required for TM repair. Furthermore, in vitro biodegradation assay highlighted a favorable influence of CN in accelerating the scaffold degradation over a period of one year. Finally, the oto- and cytocompatibility response of the nanocomposite substrates corroborated their biological relevance for the reconstruction of perforated eardrums.