| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Domingues, Rui M. A.
University of Minho
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (18/18 displayed)
- 2024Guiding Stem Cell Tenogenesis by Modulation of Growth Factor Signaling and Cell‐Scale Biophysical Cues in Bioengineered Constructscitations
- 2024Hierarchical Design of Tissue‐Mimetic Fibrillar Hydrogel Scaffoldscitations
- 2022Bioengineered 3D Living Fibers as In Vitro Human Tissue Models of Tendon Physiology and Pathologycitations
- 2022Controlling the fate of regenerative cells with engineered platelet-derived extracellular vesiclescitations
- 2022MULTIFUNCTIONAL SURFACES WITH CELL-INSTRUCTIVE AND ANTIBACTERIAL PROPERTIES
- 2022Highly elastic and bioactive bone biomimetic scaffolds based on platelet lysate and biomineralized cellulose nanocrystalscitations
- 2022Texturing Hierarchical Tissues by Gradient Assembling of Microengineered Platelet-Lysates Activated Fiberscitations
- 2022Magnetically‐Assisted 3D Bioprinting of Anisotropic Tissue‐Mimetic Constructscitations
- 2021Engineering next-generation bioinks with nanoparticles: moving from reinforcement fillers to multifunctional nanoelementscitations
- 2021Epitope-imprinted polymers: Design principles of synthetic binding partners for natural biomacromoleculescitations
- 2021Multifunctional Surfaces for Improving Soft Tissue Integrationcitations
- 2021Epitope‐Imprinted Nanoparticles as Transforming Growth Factor‐β3 Sequestering Ligands to Modulate Stem Cell Fatecitations
- 20213D Bioprinting of Miniaturized Tissues Embedded in Self‐Assembled Nanoparticle‐Based Fibrillar Platformscitations
- 2020Cellulose nanocrystals of variable sulfation degrees can sequester specific platelet lysate-derived biomolecules to modulate stem cell responsecitations
- 2019Human platelet lysate-based nanocomposite bioink for bioprinting hierarchical fibrillar structurescitations
- 2018Human-based fibrillar nanocomposite hydrogels as bioinstructive matrices to tune stem cell behaviorcitations
- 2018Engineering magnetically responsive tropoelastin spongy-like hydrogels for soft tissue regenerationcitations
- 2014The potential of cellulose nanocrystals in tissue engineering strategiescitations
Places of action
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article
Highly elastic and bioactive bone biomimetic scaffolds based on platelet lysate and biomineralized cellulose nanocrystals
Abstract
Bone is a vascularized organic-inorganic composite tissue that shows a heavily-mineralized extracellular matrix (ECM) on the nanoscale. Herein, the nucleation of calcium phosphates during the biomineralization process was mimicked using negatively-charged cellulose nanocrystals (CNCs). These mineralized-CNCs were combined with platelet lysate to produce nanocomposite scaffolds through cryogelation to mimic bone ECM protein-mineral composite nature and take advantage of the bioactivity steaming from platelet-derived biomolecules. The nanocomposite scaffolds showed high microporosity (94â 95%), high elasticity (recover from 75% strain cycles), injectability, and modulated platelet-derived growth factors sequestration and release. Furthermore, they increased alkaline phosphatase activity (up to 10-fold) and up-regulated the expression of bone-related markers (up to 2-fold), without osteogenic supplementation, demonstrating their osteoinductive properties. Also, the scaffolds promoted the chemotaxis of endothelial cells and enhanced the expression of endothelial markers, showing proangiogenic potential. These results suggest that the mineralized nanocomposite scaffolds can enhance bone regeneration by simultaneously promoting osteogenesis and angiogenesis. ; We acknowledge the financial support from Research Council of Norway for project no. 287953 and from Portuguese Foundation for Science and Technology (FCT) for CEECIND/01375/2017 to MGF and 2020.03410.CEECIND to RMAD. We also acknowledge Dr. Margarida Miranda (3B's Research Group, University of Minho) for the TGA analysis.