| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Gomez-Florit, Manuel
Health Research Institute of the Balearic Islands
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (8/8 displayed)
- 2022Bioengineered 3D Living Fibers as In Vitro Human Tissue Models of Tendon Physiology and Pathologycitations
- 2022MULTIFUNCTIONAL SURFACES WITH CELL-INSTRUCTIVE AND ANTIBACTERIAL PROPERTIES
- 2022Highly elastic and bioactive bone biomimetic scaffolds based on platelet lysate and biomineralized cellulose nanocrystalscitations
- 2022Antibacterial nanopatterned coatings for dental implantscitations
- 2022Magnetically‐Assisted 3D Bioprinting of Anisotropic Tissue‐Mimetic Constructscitations
- 2021Engineering next-generation bioinks with nanoparticles: moving from reinforcement fillers to multifunctional nanoelementscitations
- 2021Magnetic nanocomposite hydrogels for tissue engineering: design concepts and remote actuation strategies to control cell fatecitations
- 2019Injectable and magnetic responsive hydrogels with bioinspired ordered structurescitations
Places of action
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article
Highly elastic and bioactive bone biomimetic scaffolds based on platelet lysate and biomineralized cellulose nanocrystals
Abstract
Bone is a vascularized organic-inorganic composite tissue that shows a heavily-mineralized extracellular matrix (ECM) on the nanoscale. Herein, the nucleation of calcium phosphates during the biomineralization process was mimicked using negatively-charged cellulose nanocrystals (CNCs). These mineralized-CNCs were combined with platelet lysate to produce nanocomposite scaffolds through cryogelation to mimic bone ECM protein-mineral composite nature and take advantage of the bioactivity steaming from platelet-derived biomolecules. The nanocomposite scaffolds showed high microporosity (94â 95%), high elasticity (recover from 75% strain cycles), injectability, and modulated platelet-derived growth factors sequestration and release. Furthermore, they increased alkaline phosphatase activity (up to 10-fold) and up-regulated the expression of bone-related markers (up to 2-fold), without osteogenic supplementation, demonstrating their osteoinductive properties. Also, the scaffolds promoted the chemotaxis of endothelial cells and enhanced the expression of endothelial markers, showing proangiogenic potential. These results suggest that the mineralized nanocomposite scaffolds can enhance bone regeneration by simultaneously promoting osteogenesis and angiogenesis. ; We acknowledge the financial support from Research Council of Norway for project no. 287953 and from Portuguese Foundation for Science and Technology (FCT) for CEECIND/01375/2017 to MGF and 2020.03410.CEECIND to RMAD. We also acknowledge Dr. Margarida Miranda (3B's Research Group, University of Minho) for the TGA analysis.