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Naji, M. |
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Motta, Antonella |
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Aletan, Dirar |
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Mohamed, Tarek |
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Ertürk, Emre |
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Taccardi, Nicola |
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Kononenko, Denys |
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Petrov, R. H. | Madrid |
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Alshaaer, Mazen | Brussels |
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Bih, L. |
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Casati, R. |
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Muller, Hermance |
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Kočí, Jan | Prague |
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Šuljagić, Marija |
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Kalteremidou, Kalliopi-Artemi | Brussels |
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Azam, Siraj |
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Ospanova, Alyiya |
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Blanpain, Bart |
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Ali, M. A. |
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Popa, V. |
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Rančić, M. |
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Ollier, Nadège |
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Azevedo, Nuno Monteiro |
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Landes, Michael |
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Rignanese, Gian-Marco |
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Kim, S.
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (21/21 displayed)
- 2024Revisiting the use of the EORTC QLQ-STO22 to assess health-related quality of life of patients with gastric cancer: incorporating updated treatment options and cross-cultural perspectives
- 2023Compressive effects in melting of palladium thin films studied by ultrafast x-ray diffraction
- 2023Thin solid electrolyte separators for solid-state lithium–sulfur batteriescitations
- 2022Multiple proliferation signaling pathways are modulated by octacalcium phosphate in osteoblasts.citations
- 2022A tag-and-count approach for quantifying surface silanol densities on fused silica based on atomic layer deposition and high-sensitivity low-energy Ion scatteringcitations
- 2022Analysis of the Microstructure Role in the Yield Asymmetry of Extruded Mg-LPSO Alloys Using In Situ Diffraction Experimentscitations
- 2021Exfoliated bentonite/alginate nanocomposite hydrogel enhances intestinal delivery of probiotics by resistance to gastric pH and on-demand disintegration.citations
- 2020Strong Metal-Adsorbate Interactions Increase the Reactivity and Decrease the Orientational Order of OH-Functionalized N-Heterocyclic Carbene Monolayerscitations
- 2020Materials for hydrogen-based energy storage – past, recent progress and future outlookcitations
- 2020Mechanically interlocked 3D multi-material micromachinescitations
- 2016Luminescence from single CdSe nanocrystals embedded in ZnO thin films using atomic layer depositioncitations
- 2016Photoemission and electron-energy-loss-spectroscopy study of BaRuO3.citations
- 2015Reverse tension /compression asymmetry of a Mg–Y–Zn alloyscitations
- 2015Plasticity analysis by synchrotron radiation in a $Mg_{97}Y_{2}Zn_{1}$ alloy with bimodal grain structure and containing LPSO phasecitations
- 2012Measurements of the T2K neutrino beam properties using the INGRID on-axis near detectorcitations
- 2011Quantification of Temperature Driven Flow in a Polymer Electrolyte Fuel Cell Using High-Resolution Neutron Radiographycitations
- 2010Polymerization of lignosulfonates by the laccase-HBT (1-hydroxybenzotriazole) system improves dispersibilitycitations
- 2009Integrated wireless neural interface based on the Utah electrode arraycitations
- 2008Oxygen diffusion in nanocrystalline yttria-stabilized zirconia: the effect of grain boundaries
- 2007System integration of the utah electrode array using a biocompatible flip chip under bump metallization schemecitations
- 2006Direct evidence of electron accumulation in the grain boundary of yttria doped nanocrystalline zirconia ceramics
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article
Exfoliated bentonite/alginate nanocomposite hydrogel enhances intestinal delivery of probiotics by resistance to gastric pH and on-demand disintegration.
Abstract
In this study, we developed Lactobacillus rhamnosus GG (LGG)-encapsulating exfoliated bentonite/alginate nanocomposite hydrogels for protecting probiotics by delaying gastric fluid penetration into the nanocomposite and their on-demand release in the intestine. The pore size of the bentonite/alginate nanocomposite hydrogels (BA15) was two-fold smaller than that of alginate hydrogel (BA00). Following gastric pH challenge, the survival of LGG in BA15 decreased by only 1.43 log CFU/g as compared to the 6.25 log CFU/g decrease in alginate (BA00). Further, the internal pH of BA15 decreased more gradually than that of BA00. After oral administration in mice, BA15 maintained shape integrity during gastric passage, followed by appropriate disintegration within the target intestinal area. Additionally, a fecal recovery experiment in mice showed that the viable counts of LGG in BA15 were six-fold higher than those in BA00. The findings suggest the exfoliated bentonite/alginate nanocomposite hydrogel as a promising platform for intestinal delivery of probiotics.