| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Raum, Kay
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (14/14 displayed)
- 2024The respective and dependent effects of scattering and bone matrix absorption on ultrasound attenuation in cortical bone.citations
- 2021Anisotropic elastic properties of human cortical bone tissue inferred from inverse homogenization and resonant ultrasound spectroscopycitations
- 2020Cortical thinning and accumulation of large cortical pores in the tibia reflect local structural deterioration of the femoral neckcitations
- 2019Large cortical bone pores in the tibia are associated with proximal femur strengthcitations
- 2019Acoustic diffusion constant of cortical bone: Numerical simulation study of the effect of pore size and pore density on multiple scattering.citations
- 2016Multimodal correlative investigation of the interplaying micro-architecture, chemical composition and mechanical properties of human cortical bone tissue reveals predominant role of fibrillar organization in determining microelastic tissue properties.citations
- 2015Distribution of mesoscale elastic properties and mass density in the human femoral shaft.citations
- 2014Ultrasound to assess bone quality.citations
- 20143D Raman mapping of the collagen fibril orientation in human osteonal lamellae.citations
- 2014On the elastic properties of mineralized turkey leg tendon tissue: multiscale model and experiment.citations
- 2014Modeling of femoral neck cortical bone for the numerical simulation of ultrasound propagation.citations
- 2014Ultrasound biomicroscopy (UBM) and scanning acoustic microscopy (SAM) for the assessment of hernia mesh integration: a comparison to standard histology in an experimental model.citations
- 2014Multiscale, Converging Defects of Macro-Porosity, Microstructure and Matrix Mineralization Impact Long Bone Fragility in NF1citations
- 2009Assessment of Microelastic Properties of Bone Using Scanning Acoustic Microscopy: A Face-to-Face Comparison with Nanoindentation
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article
Cortical thinning and accumulation of large cortical pores in the tibia reflect local structural deterioration of the femoral neck
Abstract
<p>Introduction: Cortical bone thinning and a rarefaction of the trabecular architecture represent possible causes of increased femoral neck (FN) fracture risk. Due to X-ray exposure limits, the bone microstructure is rarely measurable in the FN of subjects but can be assessed at the tibia. Here, we studied whether changes of the tibial cortical microstructure, which were previously reported to be associated with femur strength, are also associated with structural deteriorations of the femoral neck. Methods: The cortical and trabecular architectures in the FN of 19 humans were analyzed ex vivo on 3D microcomputed tomography images with 30.3 μm voxel size. Cortical thickness (Ct.Th<sub>tibia</sub>), porosity (Ct.Po<sub>tibia</sub>) and pore size distribution in the tibiae of the same subjects were measured using scanning acoustic microscopy (12 μm pixel size). Femur strength during sideways falls was simulated with homogenized voxel finite element models. Results: Femur strength was associated with the total (vBMD<sub>tot</sub>; R<sup>2</sup> = 0.23, p < 0.01) and trabecular (vBMD<sub>trab</sub>; R<sup>2</sup> = 0.26, p < 0.01) volumetric bone mineral density (vBMD), with the cortical thickness (Ct.Th<sub>FN</sub>; R<sup>2</sup> = 0.29, p < 0.001) and with the trabecular bone volume fraction (Tb.BV/TV<sub>FN</sub>; R<sup>2</sup> = 0.34, p < 0.001), separation (Tb.Sp<sub>FN</sub>; R<sup>2</sup> = 0.25, p < 0.01) and number (Tb.N<sub>FN</sub>; R<sup>2</sup> = 0.32, p < 0.001) of the femoral neck. Moreover, smaller Ct.Th<sub>tibia</sub> was associated with smaller Ct.Th<sub>FN</sub> (R<sup>2</sup> = 0.31, p < 0.05), lower Tb.BV/TV<sub>FN</sub> (R<sup>2</sup> = 0.29, p < 0.05), higher Tb.Sp<sub>FN</sub> (R<sup>2</sup> = 0.33, p < 0.05) and lower Tb.N<sub>FN</sub> (R<sup>2</sup> = 0.42, p < 0.01). A higher prevalence of pores with diameter > 100 μm in tibial cortical bone (relCt.Po<sub>100μm-tibia</sub>) indicated higher Tb.Sp<sub>FN</sub> (R<sup>2</sup> = 0.36, p < 0.01) and lower Tb.N<sub>FN</sub> (R<sup>2</sup> = 0.45, p < 0.01). Conclusion: Bone resorption and structural decline of the femoral neck may be identified in vivo by measuring cortical bone thickness and large pores in the tibia.</p>