| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Tovar, Nick
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (14/14 displayed)
- 20233D Printing Type 1 Bovine Collagen Scaffolds for Tissue Engineering Applications—Physicochemical Characterization and In Vitro Evaluationcitations
- 2023Engineering 3D Printed Bioceramic Scaffolds to Reconstruct Critical-Sized Calvaria Defects in a Skeletally Immature Pig Modelcitations
- 2022Residual stress estimated by nanoindentation in pontics and abutments of veneered zirconia fixed dental prosthesescitations
- 2022Physiochemical and bactericidal activity evaluationcitations
- 2021Three-Dimensionally-Printed Bioactive Ceramic Scaffoldscitations
- 2021Effect of supplemental acid-etching on the early stages of osseointegrationcitations
- 2020Assessing osseointegration of metallic implants with boronized surface treatmentcitations
- 2019Synergistic effects of implant macrogeometry and surface physicochemical modifications on osseointegrationcitations
- 2019Repair of Critical-Sized Long Bone Defects Using Dipyridamole-Augmented 3D-Printed Bioactive Ceramic Scaffoldscitations
- 2018Form and functional repair of long bone using 3D-printed bioactive scaffoldscitations
- 2014The physicochemical characterization and in vivo response of micro/nanoporous bioactive ceramic particulate bone graft materialscitations
- 2014The in vivo effect of P-15 coating on early osseointegrationcitations
- 2014Nanometer-scale features on micrometer-scale surface texturingcitations
- 2012Physicochemical characterization and in vivo evaluation of amorphous and partially crystalline calcium phosphate coatings fabricated on Ti-6Al-4V implants by the plasma spray methodcitations
Places of action
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article
Nanometer-scale features on micrometer-scale surface texturing
Abstract
<p>Micro- and nanoscale surface modifications have been the focus of multiple studies in the pursuit of accelerating bone apposition or osseointegration at the implant surface. Here, we evaluated histological and nanomechanical properties, and gene expression, for a microblasted surface presenting nanometer-scale texture within a micrometer-scale texture (MB) (Ossean™ Surface, Intra-Lock International, Boca Raton, FL) versus a dual-acid etched surface presenting texture at the micrometer-scale only (AA), in a rodent femur model for 1, 2, 4, and 8. weeks in vivo. Following animal sacrifice, samples were evaluated in terms of histomorphometry, biomechanical properties through nanoindentation, and gene expression by real-time quantitative reverse transcription polymerase chain reaction analysis. Although the histomorphometric, and gene expression analysis results were not significantly different between MB and AA at 4 and 8. weeks, significant differences were seen at 1 and 2. weeks. The expression of the genes encoding collagen type I (COL-1), and osteopontin (OPN) was significantly higher for MB than for AA at 1. week, indicating up-regulated osteoprogenitor and osteoblast differentiation. At 2. weeks, significantly up-regulated expression of the genes for COL-1, runt-related transcription factor 2 (RUNX-2), osterix, and osteocalcin (OCN) indicated progressive mineralization in newly formed bone. The nanomechanical properties tested by the nanoindentation presented significantly higher-rank hardness and elastic modulus for the MB compared to AA at all time points tested. In conclusion, the nanotopographical featured surfaces presented an overall higher host-to-implant response compared to the microtextured only surfaces. The statistical differences observed in some of the osteogenic gene expression between the two groups may shed some insight into the role of surface texture and its extent in the observed bone healing mechanisms.</p>