| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Ferreira, D.
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (15/15 displayed)
- 2024Cytotoxic leuconoxine-type diazaspiroindole alkaloids isolated from Cryptolepis dubia.citations
- 2019Bio-based materials for food packaging applications
- 2019Multifunctional fibrous structures based on graphene nanoplatelets, chitosan and natural fibres
- 2019Smart green composites reinforced with graphene nanoplatelets and carbon nanotubes
- 2019CBRNe military protection: the potential of natural fibres and metal oxide nanoparticles
- 2019Multifunctional flax fibres based on the combined effect of silver and zinc oxide (Ag/ZnO) nanostructures
- 2019Applications of nanocellulose: Review and future perspectives
- 2019Biodegradable films reinforced with cellulose nanocrystals and natural extracts for food packing applications
- 2019Development of Chitosan-Gelatin nanofibers with cellulose nanocrystals for wound dressing applications
- 2019Electrospun natural nanofibres with bioactive plant extracts for therapeutic applications
- 2019Smart natural fibers based on graphene nanoplatelets and biodegradable polymers
- 2018Development of PLGA nanoparticles loaded with clofazimine for oral delivery: Assessment of formulation variables and intestinal permeabilitycitations
- 2018Mucoadhesive chitosan-coated solid lipid nanoparticles for better management of tuberculosiscitations
- 2018Soldier monitoring systems: the potential of natural fibres and metal oxide nanoparticles
- 2016Design and statistical modeling of mannose-decorated dapsone-containing nanoparticles as a strategy of targeting intestinal M-cellscitations
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article
Cytotoxic leuconoxine-type diazaspiroindole alkaloids isolated from Cryptolepis dubia.
Abstract
Two leuconoxine-type diazaspiroindole alkaloids, the known compound, (+)-melodinine E (1), and its new analogue, (+)-11-chloromelodinine E (2), were isolated from the stems of Cryptolepis dubia (Burm.f.) M.R. Almeida (Apocynaceae), collected in Laos. The chemical structures of these compounds were determined by analysis of their spectroscopic data and by comparison of these data with literature values, of which the molecular structure of 1 has been determined previously by analysis of its single-crystal X-ray diffraction data. The absolute configurations of 1 and 2 have been defined by their experimental and simulated electronic circular dichroism (ECD) spectroscopic data and supported by <sup>1</sup>H and <sup>13</sup>C NMR-based DP4+ probability analysis and specific rotation calculations. When tested against a small panel of human cancer cell lines, these two compounds exhibited selective cytotoxicity toward OVCAR3 human ovarian cancer cells.