| People | Locations | Statistics |
|---|---|---|
| Naji, M. |
| |
| Motta, Antonella |
| |
| Aletan, Dirar |
| |
| Mohamed, Tarek |
| |
| Ertürk, Emre |
| |
| Taccardi, Nicola |
| |
| Kononenko, Denys |
| |
| Petrov, R. H. | Madrid |
|
| Alshaaer, Mazen | Brussels |
|
| Bih, L. |
| |
| Casati, R. |
| |
| Muller, Hermance |
| |
| Kočí, Jan | Prague |
|
| Šuljagić, Marija |
| |
| Kalteremidou, Kalliopi-Artemi | Brussels |
|
| Azam, Siraj |
| |
| Ospanova, Alyiya |
| |
| Blanpain, Bart |
| |
| Ali, M. A. |
| |
| Popa, V. |
| |
| Rančić, M. |
| |
| Ollier, Nadège |
| |
| Azevedo, Nuno Monteiro |
| |
| Landes, Michael |
| |
| Rignanese, Gian-Marco |
|
Liebi, Marianne
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (13/13 displayed)
- 2024Unveiling breast cancer metastasis through an advanced X-ray imaging approachcitations
- 2024Phase-separated polymer blends for controlled drug delivery by tuning morphologycitations
- 2024Iron-carbohydrate complexes treating iron anaemia: Understanding the nano-structure and interactions with proteins through orthogonal characterisationcitations
- 2023SAXS imaging reveals optimized osseointegration properties of bioengineered oriented 3D-PLGA/aCaP scaffolds in a critical size bone defect model.citations
- 2023Small-angle scattering tensor tomography algorithm for robust reconstruction of complex texturescitations
- 2022Photoresponsive movement in 3D printed cellulose nanocompositescitations
- 2022Amphiphilic polymer co-network: a versatile matrix for tailoring the photonic energy transfer in wearable energy harvesting devicescitations
- 2020Validation study of small-angle X-ray scattering tensor tomographycitations
- 2019High-speed tensor tomography: iterative reconstruction tensor tomography (IRTT) algorithmcitations
- 2018Small-angle X-ray scattering tensor tomography : Model of the three-dimensional reciprocal-space map, reconstruction algorithm and angular sampling requirementscitations
- 2018Bioinspired Structural Hierarchy within Macroscopic Volumes of Synthetic Compositescitations
- 2015Six-dimensional real and reciprocal space small-angle X-ray scattering tomographycitations
- 2015Nanostructure surveys of macroscopic specimens by small-angle scattering tensor tomographycitations
Places of action
| Organizations | Location | People |
|---|
article
SAXS imaging reveals optimized osseointegration properties of bioengineered oriented 3D-PLGA/aCaP scaffolds in a critical size bone defect model.
Abstract
Healing large bone defects remains challenging in orthopedic surgery and is often associated with poor outcomes and complications. A major issue with bioengineered constructs is achieving a continuous interface between host bone and graft to enhance biological processes and mechanical stability. In this study, we have developed a new bioengineering strategy to produce oriented biocompatible 3D PLGA/aCaP nanocomposites with enhanced osseointegration. Decellularized scaffolds -containing only extracellular matrix- or scaffolds seeded with adipose-derived mesenchymal stromal cells were tested in a mouse model for critical size bone defects. In parallel to micro-CT analysis, SAXS tensor tomography and 2D scanning SAXS were employed to determine the 3D arrangement and nanostructure within the critical-sized bone. Both newly developed scaffold types, seeded with cells or decellularized, showed high osseointegration, higher bone quality, increased alignment of collagen fibers and optimal alignment and size of hydroxyapatite minerals.