| People | Locations | Statistics |
|---|---|---|
| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Oliveira, Ana L.
Universidade Católica Portuguesa
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (23/23 displayed)
- 2022Adenosine-loaded silk fibroin aerogel particles for wound healing
- 2022Opening new avenues for bioceramicscitations
- 2021New prospects in skin regeneration and repair using nanophased hydroxyapatite embedded in collagen nanofiberscitations
- 2021High efficient strategy for the production of hydroxyapatite/silk sericin nanocompositescitations
- 2020Hydroxyapatite/sericin compositescitations
- 2020High efficient strategy for the production of hydroxyapatite/silk sericin nanocomposites
- 2020Hydroxyapatite/sericin composites:a simple synthesis route under near-physiological conditions of temperature and pH and preliminary study of the effect of sericin on the biomineralization processcitations
- 2019Sterile and dual-porous aerogels scaffolds obtained through a multistep supercritical CO2-based approachcitations
- 2019Sterile and dual-porous aerogels scaffolds obtained through a multistep supercritical CO 2 -based approachcitations
- 2018Combinatory approach for developing silk fibroin scaffolds for cartilage regenerationcitations
- 2017Modulating cell adhesion to polybutylene succinate biotextile constructs for tissue engineering applicationscitations
- 2017Silk-based anisotropical 3D biotextiles for bone regenerationcitations
- 2017Core-shell silk hydrogels with spatially tuned conformations as drug-delivery systemcitations
- 2016Combinatory approach for developing silk fibroin-based scaffolds with hierarchical porosity and enhanced performance for cartilage tissue engineering applications
- 2013Evaluation of novel 3D architectures based on knitting technologies for engineering biological tissues
- 2012Aligned silk-based 3-D architectures for contact guidance in tissue engineeringcitations
- 2009Nucleation and growth of biomimetic apatite layers on 3D plotted biodegradable polymeric scaffoldscitations
- 2005Study of the influence of β-radiation on the properties and mineralization of different starch-based biomaterialscitations
- 2004Pre-mineralisation of starch/polycrapolactone bone tissue engineering scaffolds by a calcium-silicate-based processcitations
- 2003Biomimetic coating of starch based polymeric foams produced by a calcium silicate based methodologycitations
- 2003Bi-composite sandwich moldingscitations
- 2003Sodium silicate gel as a precursor for the in vitro nucleation and growth of a bone-like apatite coating in compact and porous polymeric structurescitations
- 2001Sodium silicate gel induced self-mineralization of different compact and porous polymeric structurescitations
Places of action
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article
Silk-based anisotropical 3D biotextiles for bone regeneration
Abstract
<p>Bone loss in the craniofacial complex can been treated using several conventional therapeutic strategies that face many obstacles and limitations. In this work, novel three-dimensional (3D) biotextile architectures were developed as a possible strategy for flat bone regeneration applications. As a fully automated processing route, this strategy as potential to be easily industrialized. Silk fibroin (SF) yarns were processed into weft-knitted fabrics spaced by a monofilament of polyethylene terephthalate (PET). A comparative study with a similar 3D structure made entirely of PET was established. Highly porous scaffolds with homogeneous pore distribution were observed using micro-computed tomography analysis. The wet state dynamic mechanical analysis revealed a storage modulus In the frequency range tested, the storage modulus values obtained for SF-PET scaffolds were higher than for the PET scaffolds. Human adipose-derived stem cells (hASCs) cultured on the SF-PET spacer structures showed the typical pattern for ALP activity under osteogenic culture conditions. Osteogenic differentiation of hASCs on SF-PET and PET constructs was also observed by extracellular matrix mineralization and expression of osteogenic-related markers (osteocalcin, osteopontin and collagen type I) after 28 days of osteogenic culture, in comparison to the control basal medium. The quantification of convergent macroscopic blood vessels toward the scaffolds by a chick chorioallantoic membrane assay, showed higher angiogenic response induced by the SF-PET textile scaffolds than PET structures and gelatin sponge controls. Subcutaneous implantation in CD-1 mice revealed tissue ingrowth's accompanied by blood vessels infiltration in both spacer constructs. The structural adaptability of textile structures combined to the structural similarities of the 3D knitted spacer fabrics to craniofacial bone tissue and achieved biological performance, make these scaffolds a possible solution for tissue engineering approaches in this area.</p>