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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Simon, F.
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (15/15 displayed)
- 2023Ultralong 100 ns spin relaxation time in graphite at room temperaturecitations
- 2022Dopamine as a bioinspired adhesion promoter for the metallization of multi-responsive phase change microcapsulescitations
- 2020Ultralong Spin Lifetime in Light Alkali Atom Doped Graphenecitations
- 2019An efficient two-polymer binder for high-performance silicon nanoparticle-based lithium-ion batteries: A systematic case study with commercial polyacrylic acid and polyvinyl butyral polymers
- 2019Vanadium salt assisted solvothermal reduction of graphene oxide and the thermoelectric characterisation of the reduced graphene oxide in bulk and as compositecitations
- 2018Polyethenetetrathiolate or polytetrathiooxalate? Improved synthesis, a comparative analysis of a prominent thermoelectric polymer and implications to the charge transport mechanismcitations
- 2016Nanostructured Aniline Formaldehyde Resin/Polysilazane Hybrid Materials by Twin Polymerizationcitations
- 2015Transport, magnetic and vibrational properties of chemically exfoliated few- layer graphene
- 2013Poly(lactic acid) composites with poly(lactic acid)-modified carbon nanotubescitations
- 2012Carboxylated nitrile butadiene rubber/hybrid filler composites
- 2012Sulphur-doped porous carbon from a thiophene-based twin monomercitations
- 2012Intelligent Materials with Adaptive Adhesion Properties Based on Comb-like Polymer Brushescitations
- 2011Deposition of poly(ethyleneimine)/poly(2-ethyl-2-oxazoline) based comb-branched polymers onto polypropylene nonwoven fabric using the layer-by-layer technique. selected properties of the modified materialscitations
- 2007Multiwalled carbon nanotubes produced by a continuous CVD method and their use in melt mixed composites with polycarbonatecitations
- 2004In vitro blood compatibility of polymeric biomaterials through covalent immobilization of an amidine derivativecitations
Places of action
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article
In vitro blood compatibility of polymeric biomaterials through covalent immobilization of an amidine derivative
Abstract
We present a surface coating with anticoagulant characteristics showing significantly reduced coagulation activation. The synthesis of a monomeric conjugate containing a benzamidine moiety was carried out and its inhibitory activity against human thrombin, the key enzyme of the blood coagulation cascade, was determined using a chromogenic assay. Based on that, low-thrombogenic interfaces were prepared by covalent attachment of this low-molecular weight thrombin inhibitor on poly(octadecene-alt-maleic anhydride) copolymer thin films and characterized using ellipsometry, XPS and dynamic contact angle measurements. The in vitro hemocompatibility tests using freshly drawn human whole blood showed, in agreement with the SEM images, that a PO-MA film modified with a benzamidine moiety using a PEG spacer decreased the activation of coagulation, platelets and the complement system. The decreased protein adsorption, in addition to the specific inhibition of thrombin, effectively enhanced the short-term hemocompatibility characteristics. (C) 2003 Elsevier Ltd. All rights reserved.