| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Dubruel, Peter
Ghent University
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (31/31 displayed)
- 2024Tailorable acrylate-endcapped urethane-based polymers for precision in digital light processing : versatile solutions for biomedical applicationscitations
- 2023Polymeric reinforcements for cellularized collagen-based vascular wall models: influence of the scaffold architecture on the mechanical and biological propertiescitations
- 2023Printability evaluation of UV-curable aqueous laponite/urethane-based PEG inkscitations
- 2023Solid‐state crosslinkable, shape‐memory polyesters serving tissue engineeringcitations
- 2023Microstructured Optical Fiber Made From Biodegradable and Biocompatible Poly(D,L-Lactic Acid) (PDLLA)citations
- 2021Increasing the Microfabrication Performance of Synthetic Hydrogel Precursors through Molecular Designcitations
- 2021Capacitive sensing of an amphetamine drug precursor in aqueous samples : application of novel molecularly imprinted polymers for benzyl methyl ketone detectioncitations
- 2021Capacitive sensing of an amphetamine drug precursor in aqueous samples : application of novel molecularly imprinted polymers for benzyl methyl ketone detectioncitations
- 2021Increasing the microfabrication performance of synthetic hydrogel precursors through molecular designcitations
- 2020On the Characterization of Novel Step-Index Biocompatible and Biodegradable poly(D,L-lactic acid) Based Optical Fibercitations
- 2019Amorphous random copolymers of lacOCA and manOCA for the design of biodegradable polyesters with tuneable propertiescitations
- 2019Amorphous random copolymers of lacOCA and manOCA for the design of biodegradable polyesters with tuneable propertiescitations
- 2018Clear to clear laser welding for joining thermoplastic polymers: A comparative study based on physicochemical characterizationcitations
- 2018Ultrathin Poly-DL-Lactic Membranes for Corneal Endothelial Transplantation
- 2018Localized optical- quality doping of graphene on silicon waveguides through a TFSA- containing polymer matrixcitations
- 2018Ring opening copolymerisation of lactide and mandelide for the development of environmentally degradable polyesters with controllable glass transition temperaturescitations
- 2017Combinatory approach of methacrylated alginate and acid monomers for concrete applicationscitations
- 2017Characterization of methacrylated polysaccharides in combination with amine-based monomers for application in mortarcitations
- 2016Indirect solid freeform fabrication of an initiator-free photocrosslinkable hydrogel precursor for the creation of porous scaffoldscitations
- 2016Deep proton writing with 12 MeV protons for rapid prototyping of microstructures in polymethylmethacrylatecitations
- 2016Chapter 21 – Biodegradable polyesters: from monomer to application
- 2015Autogenous healing of cementitious materials promoted by superabsorbent polymers studied by means of X-ray computed microtomography
- 2014Direct synthesis and morphological characterization of gold-dendrimer nanocomposites prepared using PAMAM succinamic acid dendrimers: preliminary study of the calcification potential
- 2013Magnesium-enhanced enzymatically mineralized platelet-rich fibrin for bone regeneration applicationscitations
- 2012Implantable (bio)polymer coated titanium scaffolds : a reviewcitations
- 2011Gelatin functionalization of biomaterial surfaces : strategies for immobilization and visualizationcitations
- 2011Photonic crystal fiber Bragg grating based sensors: opportunities for applications in healthcarecitations
- 2011Surface modification of a photo definable epoxy resin with polydopamine to improve adhesion with electroless deposited copper
- 2011Surface modification of a photo definable epoxy resin with polydopamine to improve adhesion with electroless deposited copper
- 2011Photonic crystal fiber Bragg grating based sensorscitations
- 2008Flexible materials for optical applications
Places of action
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article
Tailorable acrylate-endcapped urethane-based polymers for precision in digital light processing : versatile solutions for biomedical applications
Abstract
Bioengineering seeks to replicate biological tissues exploiting scaffolds often based on polymeric biomaterials. Digital light processing (DLP) has emerged as a potent technique to fabricate tissue engineering (TE) scaffolds. However, the scarcity of suitable biomaterials with desired physico-chemical properties along with processing capabilities limits DLP's potential. Herein, we introduce acrylate-endcapped urethane-based polymers (AUPs) for precise physico-chemical tuning while ensuring optimal computer-aided design/computer-aided manufacturing (CAD/CAM) mimicry. Varying the polymer backbone (i.e. poly(ethylene glycol) (PEG) versus poly(propylene glycol) (PPG)) and photo-crosslinkable endcap (i.e. di-acrylate versus hexa-acrylate), we synthesized a series of photo-crosslinkable materials labeled as UPEG2, UPEG6, UPPG2 and UPPG6. Comprehensive material characterization including physico-chemical and biological evaluations, was followed by a DLP processing parametric study for each material. The impact of the number of acrylate groups per polymer (2 to 6) on the physico-chemical properties was pronounced, as reflected by a reduced swelling, lower water contact angles, accelerated crosslinking kinetics, and increased Young's moduli upon increasing the acrylate content. Furthermore, the different polymer backbones also exerted a substantial effect on the properties, including the absence of crystallinity, remarkably reduced swelling behaviors, a slight reduction in Young's modulus, and slower crosslinking kinetics for UPPG vs UPEG. The mechanical characteristics of DLP-printed samples showcased the ability to tailor the materials' stiffness (ranging from 0.4 to 5.3 MPa) by varying endcap chemistry and/or backbone. The in vitro cell assays confirmed biocompatibility of the material as such and the DLP-printed discs. Furthermore, the structural integrity of 3D scaffolds was preserved both in dry and swollen state. By adjusting the backbone chemistry or acrylate content, the post-swelling dimensions could be customized towards the targeted application. This study showcases the potential of these materials offering tailorable properties to serve many biomedical applications such as cartilage TE.