| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Plocinski, Tomasz
Warsaw University of Technology
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (15/15 displayed)
- 2024Optimization of the plasmonic properties of titanium nitride films sputtered at room temperature through microstructure and thickness controlcitations
- 2023On the Influence of Manufacturing Parameters on the Microstructure, Mechanical Properties and Corrosion Resistance of AISI 316L Steel Deposited by Laser Engineered Net Shaping (LENS®)citations
- 2023In vitro and in vivo degradation behavior of Mg-0.45Zn-0.45Ca (ZX00) screws for orthopedic applicationscitations
- 2023Comprehensive study upon physicochemical properties of bio-ZnO NCscitations
- 2023Consideration of a new approach to clarify the mechanism formation of AgNPs, AgNCl and AgNPs@AgNCl synthesized by biological methodcitations
- 2023In-depth analysis of the influence of bio-silica filler (Didymosphenia geminata frustules) on the properties of Mg matrix compositescitations
- 2023The combined effect of zinc and calcium on the biodegradation of ultrahigh-purity magnesium implantscitations
- 2023Crystallization of Na3VTi(PO4)2F3 glass: In situ observation of the function of distribution of relaxation times
- 2022Effect of annealing on the mechanical and corrosion properties of 316L stainless steel manufactured by laser powder bed fusioncitations
- 2021Design of SiC-Doped Piezoresistive Pressure Sensor for High-Temperature Applicationscitations
- 2021Influence of bimodal grain size distribution on the corrosion resistance of Mg–4Li–3Al–1Zn (LAZ431)citations
- 2021Effects of Composite Coatings Functionalized with Material Additives Applied on Textile Materials for Cut Resistant Protective Glovescitations
- 2018Structure and corrosion resistance of titanium oxide layers produced on NiTi alloy in low-temperature plasmacitations
- 2015Scandium functionalized carbon aerogel:Synthesis of nanoparticles and structure of a new ScOCl and properties of NaAlH4 as a function of pore sizecitations
- 2012Processing and characterization of a W–2Y material for fusion power reactorscitations
Places of action
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article
The combined effect of zinc and calcium on the biodegradation of ultrahigh-purity magnesium implants
Abstract
Magnesium (Mg)-based implants are promising candidates for orthopedic interventions, because of their biocompatibility, and good mechanical features, and ability to degrade completely in the body, eliminating the need for an additional removal surgery. In the present study, we synthesized and investigated two Mg-based materials, ultrahigh-purity ZX00 (Mg < 0.5Zn < 0.5Ca, in wt%; Fe-content <1 ppm) and ultrahigh-purity Mg (XHP-Mg, >99.999 wt% Mg; Fe-content <1 ppm), in vitro and in vivo in juvenile healthy rats to clarify the effect of the alloying elements Zn and Ca on mechanical properties, microstructure, cytocompatibility and degradation rate. Potential differences in bone formation and bone in-growth were also assessed and compared with state-of-the-art non-degradable titanium (Ti)-implanted, sham-operated, and control (non-intervention) groups, using micro-computed tomography, histology and scanning electron microscopy. At 6 and 24 weeks after implantation, serum alkaline phosphatase (ALP), calcium (Ca), and Mg level were measured and bone marrow stromal cells (BMSCs) were isolated for real-time PCR analysis. Results show that ZX00 implants have smaller grain size and superior mechanical properties than XHP-Mg, and that both reveal good biocompatibility in cytocompatibilty tests. ZX00 homogenously degraded with an increased gas accumulation 12 and 24 weeks after implantation, whereas XHP-Mg exhibited higher gas accumulation already at 2 weeks. Serum ALP, Ca, and Mg levels were comparable among all groups and both Mg-based implants led to similar relative expression levels of Alp, Runx2, and Bmp-2 genes at weeks 6 and 24. Histologically, Mg-based implants are superior for new bone tissue formation and bone in-growth compared to Ti implants. Furthermore, by tracking the sequence of multicolor fluorochrome labels, we observed higher mineral apposition rate at week 2 in both Mg-based implants compared to the control groups.Our findings suggest that (i) ZX00 and XHP-Mg support bone formation and remodeling, (ii) both Mg-based implants are superior to Ti implants in terms of new bone tissue formation and osseointegration, and (iii) ZX00 is more favorable due to its lower degradation rate and moderate gas accumulation.