| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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De-Juan-Pardo, Elena M.
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (10/10 displayed)
- 2023Novel hybrid biocomposites for tendon graftscitations
- 2023Silane-modified hydroxyapatite nanoparticles incorporated into polydioxanone/poly(lactide-co-caprolactone) creates a novel toughened nanocomposite with improved material properties and in vivo inflammatory responsescitations
- 2022The Technological Advancement to Engineer Next-Generation Stent-Graftscitations
- 2022Highly Elastic Scaffolds Produced by Melt Electrowriting of Poly(L-lactide-co-epsilon-caprolactone)citations
- 2020Melt Electrowriting of Complex 3D Anatomically Relevant Scaffoldscitations
- 2018Electrospinning writing with molten poly (epsilon-caprolactone) from different directions - Examining the effects of gravitycitations
- 2017Electrospinning with polymer melts - state of the art and future perspectivescitations
- 2017Melt electrospinning writing of three-dimensional poly(epsilon-caprolactone) scaffolds with controllable morphologies for tissue engineering applicationscitations
- 2017Biofabricated soft network composites for cartilage tissue engineeringcitations
- 2015Enhancing structural integrity of hydrogels by using highly organised melt electrospun fibre constructscitations
Places of action
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article
Novel hybrid biocomposites for tendon grafts
Abstract
Biopolymers play a critical role as scaffolds used in tendon and ligament (TL) regeneration. Although advanced biopolymer materials have been proposed with optimised mechanical properties, biocompatibility, degradation, and processability, it is still challenging to find the right balance between these properties. Here, we aim to develop novel hybrid biocomposites based on poly(p-dioxanone) (PDO), poly(lactide-co-caprolactone) (LCL) and silk to produce high-performance grafts suitable for TL tissue repair. Biocomposites containing 1–15% of silk were studied through a range of characterisation techniques. We then explored biocompatibility through in vitro and in vivo studies using a mouse model. We found that adding up to 5% silk increases the tensile properties, degradation rate and miscibility between PDO and LCL phases without agglomeration of silk inside the composites. Furthermore, addition of silk increases surface roughness and hydrophilicity. In vitro experiments show that the silk improved attachment of tendon-derived stem cells and proliferation over 72 h, while in vivo studies indicate that the silk can reduce the expression of pro-inflammatory cytokines after six weeks of implantation. Finally, we selected a promising biocomposite and created a prototype TL graft based on extruded fibres. We found that the tensile properties of both individual fibres and braided grafts could be suitable for anterior cruciate ligament (ACL) repair applications.