Materials Map

Discover the materials research landscape. Find experts, partners, networks.

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The Materials Map is an open tool for improving networking and interdisciplinary exchange within materials research. It enables cross-database search for cooperation and network partners and discovering of the research landscape.

The dashboard provides detailed information about the selected scientist, e.g. publications. The dashboard can be filtered and shows the relationship to co-authors in different diagrams. In addition, a link is provided to find contact information.

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The Materials Map is still under development. In its current state, it is only based on one single data source and, thus, incomplete and contains duplicates. We are working on incorporating new open data sources like ORCID to improve the quality and the timeliness of our data. We will update Materials Map as soon as possible and kindly ask for your patience.

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in Cooperation with on an Cooperation-Score of 37%

Topics

Publications (3/3 displayed)

  • 2020Interactions between PAMAM dendrimers and DOPC lipid multilayers11citations
  • 2020Interactions between PAMAM dendrimers and DOPC lipid multilayers:Membrane thinning and structural disorder11citations
  • 2017Interfacial and structural characteristics of polyelectrolyte multilayers used as cushions for supported lipid bilayers11citations

Places of action

Chart of shared publication
Bikondoa, Oier
3 / 17 shared
Slastanova, Anna
2 / 11 shared
Fox, Laura J.
2 / 4 shared
Richardson, Robert M.
2 / 17 shared
Briscoe, Wuge H.
3 / 27 shared
Taylor, Nicolas
2 / 2 shared
Warszynski, P.
1 / 2 shared
Kolasinska-Sojka, M.
1 / 1 shared
Wasilewska, M.
1 / 1 shared
Chart of publication period
2020
2017

Co-Authors (by relevance)

  • Bikondoa, Oier
  • Slastanova, Anna
  • Fox, Laura J.
  • Richardson, Robert M.
  • Briscoe, Wuge H.
  • Taylor, Nicolas
  • Warszynski, P.
  • Kolasinska-Sojka, M.
  • Wasilewska, M.
OrganizationsLocationPeople

article

Interactions between PAMAM dendrimers and DOPC lipid multilayers

  • Bikondoa, Oier
  • Wlodek, Magdalena
  • Slastanova, Anna
  • Fox, Laura J.
  • Richardson, Robert M.
  • Briscoe, Wuge H.
  • Taylor, Nicolas
Abstract

<p>Background: Understanding the structure of hybrid nanoparticle-lipid multilayers is of fundamental importance to their bioanalytical applications and nanotoxicity, where nanoparticle-membrane interactions play an important role. Poly(amidoamine) (PAMAM) dendrimers are branched polymeric nanoparticles with potential biomedical applications due to precise tunability of their physicochemical properties. Here, the effect of PAMAM dendrimers (2.9–4.5 nm) with either a hydrophilic amine (NH<sub>2</sub>) or a hydrophobic C<sub>12</sub> chain surface termination on the 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) multilayers has been studied for the first time. Methods: DOPC multilayers were created by the liposome-rupture method via drop-casting dendrimer-liposome dispersions with the dendrimers added at different concentrations and at three different stages. The multilayer structure was evaluated via the analysis of the synchrotron X-ray reflectivity (XRR) curves, obtaining the bilayer d-spacing, the coherence length from the Scherrer (L<sub>s</sub>) analysis of the Bragg peaks, and the paracrystalline disorder parameter (g). Results: Dendrimer addition led to lipid bilayer thinning and more disordered multilayer structures. Larger hydrophobic dendrimers caused greater structural disruption to the multilayers compared to the smaller dendrimers. The smallest, positively charged dendrimers at their highest concentration caused the most pronounced bilayer thinning. The dendrimer-liposome mixing method also affected the multilayer structure due to different dendrimer aggregation involved. Conclusions: These results show the complexity of the effect of dendrimer physicochemical properties and the addition method of dendrimers on the structure of mixed dendrimer-DOPC multilayers. General significance: These insights are useful for fundamental understanding of nanotoxicity and future biomedical application of nanocomposite multilayer materials in which nanoparticles are added for enhanced properties and functionality.</p>

Topics
  • nanoparticle
  • nanocomposite
  • impedance spectroscopy
  • dispersion
  • surface
  • casting
  • amine
  • dendrimer