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- 2024Silver Nanoparticles Supported onto TEMPO-Oxidized Cellulose Nanofibers for Promoting Cd2+ Cation Adsorptioncitations
- 2022Biocompatibility and antibacterial properties of TiCu(Ag) thin films produced by physical vapor deposition magnetron sputteringcitations
- 2022Biocompatibility and antibacterial properties of TiCu(Ag) thin films produced by physical vapor deposition magnetron sputteringcitations
- 2021Bioactivated Oxidized Polyvinyl Alcohol towards Next-Generation Nerve Conduits Developmentcitations
- 2021Biofunctionalization of bioactive ceramic scaffolds to increase the cell response for bone regenerationcitations
- 2021Biofunctionalization of bioactive ceramic scaffolds to increase the cell response for bone regenerationcitations
- 2019Biofunctionalization of TiO 2 Surfaces with Self-Assembling Layers of Oligopeptides Covalently Grafted to Chitosancitations
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article
Biocompatibility and antibacterial properties of TiCu(Ag) thin films produced by physical vapor deposition magnetron sputtering
Abstract
<p>Mechanical robustness, biocompatibility, and antibacterial performance are key features for materials suitable to be used in tissue engineering applications. In this work, we investigated the link existing between structural and functional properties of TiCu(Ag) thin films deposited by physical vapor deposition magnetron sputtering (MS-PVD) on Si substrates. Thin films were characterized by X-ray diffraction (XRD), nanoindentation, atomic force microscopy (AFM), and X-ray photoelectron spectroscopy (XPS). The TiCu(Ag) films showed complete amorphous structure and improved mechanical properties in comparison with pure Ti films. However, for contents in excess of 20% Ag we observed the appearance of nanometric Ag crystallite. The TiCu(Ag) thin films displayed excellent biocompatibility properties, allowing adhesion and proliferation of the human fibroblasts MRC-5 cell line. Moreover, all the investigated TiCu(Ag) alloys display bactericidal properties, preventing the growth of both Pseudomonas aeruginosa and Staphylococcus aureus. Results obtained from biological tests have been correlated to the surface structure and microstructure of films. The excellent biocompatibility and bactericidal properties of these multifunctional thin films opens to their use in tissue engineering applications.</p>