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Naji, M. |
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Motta, Antonella |
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Aletan, Dirar |
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Mohamed, Tarek |
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Ertürk, Emre |
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Taccardi, Nicola |
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Kononenko, Denys |
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Petrov, R. H. | Madrid |
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Alshaaer, Mazen | Brussels |
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Bih, L. |
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Casati, R. |
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Muller, Hermance |
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Kočí, Jan | Prague |
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Šuljagić, Marija |
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Kalteremidou, Kalliopi-Artemi | Brussels |
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Azam, Siraj |
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Ospanova, Alyiya |
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Blanpain, Bart |
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Ali, M. A. |
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Popa, V. |
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Rančić, M. |
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Ollier, Nadège |
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Azevedo, Nuno Monteiro |
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Landes, Michael |
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Rignanese, Gian-Marco |
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Jarek, Marcin
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (14/14 displayed)
- 2023Block copolymer interfaces investigated by means of NMR, atomic force microscopy and dielectric spectroscopy
- 2023Multifunctional ZnO:Gd@ZIF-8 hybrid nanocomposites with tunable luminescent-magnetic performance for potential bioapplicationcitations
- 2020Nanocomposite Gel as Injectable Therapeutic Scaffold: Microstructural Aspects and Bioactive Propertiescitations
- 2019Structural and dynamic study of block copolymer – Nanoparticles nanocompositescitations
- 2018Silver and ultrasmall iron oxides nanoparticles in hydrocolloids: Effect of magnetic field and temperature on self-organizationcitations
- 2018Cilostazol-Loaded Poly(ε-Caprolactone) Electrospun Drug Delivery System for Cardiovascular Applicationscitations
- 2018Gel with silver and ultrasmall iron oxide nanoparticles produced with Amanita muscaria extract: physicochemical characterization, microstructure analysis and anticancer propertiescitations
- 2017Self-organizing silver and ultrasmall iron oxide nanoparticles prepared with ginger rhizome extract: Characterization, biomedical potential and microstructure analysis of hydrocolloidscitations
- 2017Functionalized multimodal ZnO@Gd <inf>2</inf> O <inf>3</inf> nanosystems to use as perspective contrast agent for MRIcitations
- 2016Synthesis and study of bifunctional core-shell nanostructures based on ZnO@Gd<inf>2</inf>O<inf>3</inf>citations
- 2016The influence of oxidation process on exchange bias in egg-shaped FeO/Fe<inf>3</inf>O<inf>4</inf> core/shell nanoparticlescitations
- 2015Synthesis and characterization of magnetite/silver/antibiotic nanocomposites for targeted antimicrobial therapycitations
- 2015Atomic layer deposition TiO2 coated porous silicon surface: Structural characterization and morphological featurescitations
- 2014Phase transitions of octamethylcyclotetrasiloxane confined inside aluminosilicate and silicate nanoporous matricescitations
Places of action
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article
Functionalized multimodal ZnO@Gd <inf>2</inf> O <inf>3</inf> nanosystems to use as perspective contrast agent for MRI
Abstract
<p>The main aim of this research was the synthesis of the multimodal hybrid ZnO@Gd<sub>2</sub>O<sub>3</sub>nanostructures as prospective contrast agent for Magnetic Resonance Imaging (MRI) for bio-medical applications. The nanoparticles surface was functionalized by organosilicon compounds (OSC) then, by folic acid (FA) as targeting agent and doxorubicin (Dox) as chemotherapeutic agent. Doxorubicin and folic acid were attached to the nanoparticles surface by amino groups as well as due to attractive physical interactions. The morphology and crystallography of the nanostructures were studied by HRTEM and SAXS techniques. After ZnO nanoparticles surface modification by Gd<sup>3+</sup>and annealing at 900 °C, ZnO@Gd<sub>2</sub>O<sub>3</sub>nanostructures are polydispersed with size 30–100 nm. NMR (Nuclear Magnetic Resonance) studies of ZnO@Gd<sub>2</sub>O<sub>3</sub>were performed on fractionated particles with size up to 50 nm. Fourier transform infrared spectroscopy (FTIR), UV–vis spectroscopy, zeta-potential measurements and energy dispersive X-ray analysis (EDX) showed that functional groups have been effectively bonded onto the nanoparticles surface. The high adsorption capacity of folic acid (up to 20%) and doxorubicin (up to 40%) on nanoparticles was reached upon 15 min of adsorption process in a temperature-dependent manner. The nuclear magnetic resonance (NMR) relaxation measurements confirmed that the obtained ZnO@Gd<sub>2</sub>O<sub>3</sub>nanostructures could be good contrast agents, useful for magnetic resonance imaging.</p>