| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Pumera, Martin
Brno University of Technology
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (15/15 displayed)
- 20243D printing of MAX/PLA filament: Electrochemical in-situ etching for enhanced energy conversion and storagecitations
- 2023Heterolayered carbon allotrope architectonics via multi-material 3D printing for advanced electrochemical devicescitations
- 2022Functional metal-based 3D-printed electronics engineering: Tunability and bio-recognitioncitations
- 2022Hierarchical Atomic Layer Deposited V<sub>2</sub>O<sub>5</sub> on 3D Printed Nanocarbon Electrodes for High‐Performance Aqueous Zinc‐Ion Batteriescitations
- 2022Microrobotic carrier with enzymatically encoded drug release in the presence of pancreatic cancer cells via programmed self-destructioncitations
- 2022Versatile Design of Functional Organic-Inorganic 3D-Printed (Opto)Electronic Interfaces with Custom Catalytic Activitycitations
- 2021Organic photoelectrode engineering: accelerating photocurrent generation via donor-acceptor interactions and surface-assisted synthetic approachcitations
- 2021Organic photoelectrode engineering:accelerating photocurrent generationviadonor-acceptor interactions and surface-assisted synthetic approachcitations
- 2021Metal-plated 3D-printed electrode for electrochemical detection of carbohydratescitations
- 2021Atomic layer deposition of photoelectrocatalytic material on 3D-printed nanocarbon structures ; Depozice atomárních vrstev fotoelektrokatalytického materiálu na 3D tištěné uhlíkové nanostruktury.citations
- 20172H → 1T phase engineering of layered tantalum disulphides in electrocatalysis: oxygen reduction reactioncitations
- 2017Surface properties of MoS2 probed by inverse gas chromatography and their impact on electrocatalytic propertiescitations
- 2011Electron hopping rate measurements in ITO junctions: Charge diffusion in a layer-by-layer deposited ruthenium(II)-bis(benzimidazolyl)pyridine-phosphonate-TiO2 filmcitations
- 2005Magnetically trigged direct electrochemical detection of DNA hybridization using Au67 quantum dot as electrical tracercitations
- 2005Glucose biosensor based on carbon nanotube epoxy compositescitations
Places of action
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article
Microrobotic carrier with enzymatically encoded drug release in the presence of pancreatic cancer cells via programmed self-destruction
Abstract
The field of micro/nanorobots is at the forefront of nanotechnology research. Particularly, magnetically propelled micro/nanorobots demonstrate great potential for biomedical applications due to their biocompatibility in biological environments. Herein is a concept of magnetically powered micromachines with a biodegradable polymer and layer containing an incorporated anticancer drug. The microrobot is chemically programmed in such a way that the polymer layer is degraded by the enzymatic activity of lipase, which is overexpressed in pancreatic cancer cells. This causes degradation of the microrobot's polymer layer and, thus, destruction of this robot, releasing the anticancer drug, which in turn kills the pancreatic cancer cell. Magnetic microrobots are based on microspheres made of polycaprolactone (PCL), iron oxide nanoparticles (Fe3O4), and coated polyethyleneimine (PEI) micelles containing the anticancer drug. Lipase, naturally overexpressed specifically in pancreatic cancer cells, triggers the drug release from the micromachines through biodegradation of PCL. The developed PCL-Fe3O4/PEI magnetic microrobots are fully biocompatible and represent a promising tool for programmable drug release that may be useful in many biomedical applications. © 2022