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Schindeler, Aaron
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article
Highly substituted calcium silicates 3D printed with complex architectures to produce stiff, strong and bioactive scaffolds for bone regeneration
Abstract
<p>Bone's outstanding biomechanical performance is derived from cooperative interactions between its composition and microarchitecture. Towards developing bioceramic scaffolds with similar biomechanical performance for repairing large bone defects under load, we have developed 13 new bioceramic compositions by doping various concentrations of iron and magnesium into Baghdadite (a Zr-Ca-Silicate: Ca<sub>3</sub>ZrSi<sub>2</sub>O<sub>9</sub>). The resulting bioceramics were printed into scaffolds with precisely controlled internal and external shapes using a versatile photopolymerization-based stereolithography technique. The biomechanical performance of new compositions and scaffolds were determined using mechanical tests with in situ imaging, in vitro cell study, an in vivo animal study, histological analysis, and microcomputed tomography. Mg-doped Baghdadite with composition Ca<sub>3</sub>Mg<sub>0.1</sub>Zr<sub>0.9</sub>Si<sub>2</sub>O<sub>8.9</sub> demonstrated superior bioactivity and mechanical properties, compared to Baghdadite. 3D printed Mg-doped Baghdadite scaffolds with 35% porosity and designed architecture matched the stiffness and strength of cortical bone. These scaffolds were 2–5 times stronger than other bioceramic and bioglass scaffolds with the same porosity made with photopolymerization techniques. In vivo bone ingrowth was 2.2 times higher in Mg-doped Baghdadite than Baghdadite, effectively transforming these mechanically brittle scaffolds into deformable and tough ceramic-bone composites. Mg-doped Baghdadite scaffolds demonstrate a combination of favorable mechanical properties and bone regeneration capacity that show their potential for clinical success.</p>