| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Zreiqat, Hala
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (16/16 displayed)
- 2024Unraveling the influence of channel size and shape in 3D printed ceramic scaffolds on osteogenesiscitations
- 2024Engineering antibacterial bioceramicscitations
- 2023Design and evaluation of 3D-printed Sr-HT-Gahnite bioceramic for FDA regulatory submissioncitations
- 2023Discovering an unknown territory using atom probe tomographycitations
- 2021Redefining architectural effects in 3D printed scaffolds through rational design for optimal bone tissue regenerationcitations
- 2021Personalized Baghdadite scaffoldscitations
- 2021Highly substituted calcium silicates 3D printed with complex architectures to produce stiff, strong and bioactive scaffolds for bone regenerationcitations
- 2021Development of a bioactive and radiopaque bismuth doped baghdadite ceramic for bone tissue engineeringcitations
- 2020On design for additive manufacturing (DAM) parameter and its effects on biomechanical properties of 3D printed ceramic scaffoldscitations
- 2016Efficacy of novel synthetic bone substitutes in the reconstruction of large segmental bone defects in sheep tibiaecitations
- 2016Design and Fabrication of 3D printed Scaffolds with a Mechanical Strength Comparable to Cortical Bone to Repair Large Bone Defectscitations
- 2015Micro-poro-elasticity of baghdadite-based bone tissue engineering scaffolds: A unifying approach based on ultrasonics, nanoindentation, and homogenization theorycitations
- 2015Micro-poro-elasticity of baghdadite-based bone tissue engineering scaffolds:A unifying approach based on ultrasonics, nanoindentation, and homogenization theory
- 2014Micro-elasticity of porous ceramic baghdadite
- 2010The influence hydroxyapatite nanoparticle shape and size on the properties of biphasic calcium phosphate scaffolds coated with hydroxyapatite-PCL compositescitations
- 2009The effect of mesoporous bioactive glass on the physiochemical, biological and drug-release properties of poly(dl-lactide-co-glycolide) filmscitations
Places of action
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article
Highly substituted calcium silicates 3D printed with complex architectures to produce stiff, strong and bioactive scaffolds for bone regeneration
Abstract
<p>Bone's outstanding biomechanical performance is derived from cooperative interactions between its composition and microarchitecture. Towards developing bioceramic scaffolds with similar biomechanical performance for repairing large bone defects under load, we have developed 13 new bioceramic compositions by doping various concentrations of iron and magnesium into Baghdadite (a Zr-Ca-Silicate: Ca<sub>3</sub>ZrSi<sub>2</sub>O<sub>9</sub>). The resulting bioceramics were printed into scaffolds with precisely controlled internal and external shapes using a versatile photopolymerization-based stereolithography technique. The biomechanical performance of new compositions and scaffolds were determined using mechanical tests with in situ imaging, in vitro cell study, an in vivo animal study, histological analysis, and microcomputed tomography. Mg-doped Baghdadite with composition Ca<sub>3</sub>Mg<sub>0.1</sub>Zr<sub>0.9</sub>Si<sub>2</sub>O<sub>8.9</sub> demonstrated superior bioactivity and mechanical properties, compared to Baghdadite. 3D printed Mg-doped Baghdadite scaffolds with 35% porosity and designed architecture matched the stiffness and strength of cortical bone. These scaffolds were 2–5 times stronger than other bioceramic and bioglass scaffolds with the same porosity made with photopolymerization techniques. In vivo bone ingrowth was 2.2 times higher in Mg-doped Baghdadite than Baghdadite, effectively transforming these mechanically brittle scaffolds into deformable and tough ceramic-bone composites. Mg-doped Baghdadite scaffolds demonstrate a combination of favorable mechanical properties and bone regeneration capacity that show their potential for clinical success.</p>