| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Cox, Sophie C.
University of Birmingham
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (18/18 displayed)
- 2024A genetic algorithm optimization framework for the characterization of hyper-viscoelastic materials
- 2023Tailoring absorptivity of highly reflective Ag powders by pulsed-direct current magnetron sputtering for additive manufacturing processescitations
- 2023Tailoring absorptivity of highly reflective Ag powders by pulsed-direct current magnetron sputtering for additive manufacturing processescitations
- 2022Surface Free Energy Dominates the Biological Interactions of Postprocessed Additively Manufactured Ti-6Al-4Vcitations
- 2022Controlled Release of Epigenetically-Enhanced Extracellular Vesicles from a GelMA/Nanoclay Composite Hydrogel to Promote Bone Repaircitations
- 2022The influence of thermal oxidation on the microstructure, fatigue properties, tribological and in vitro behaviour of laser powder bed fusion manufactured Ti-34 Nb-13Ta-5Zr-0.2O alloycitations
- 2022Development, characterisation, and modelling of processability of nitinol stents using laser powder bed fusioncitations
- 2022Photocurable antimicrobial silk-based hydrogels for corneal repaircitations
- 2021Surface finish of additively manufactured metalscitations
- 2021Biofilm viability checkercitations
- 2020Optimizing the antimicrobial performance of metallic glass composites through surface texturingcitations
- 2020Selective laser melting of Ti-6Al-4V: the impact of post-processing on the tensile, fatigue and biological properties for medical implant applicationscitations
- 2020Selective laser melting of ti-6al-4vcitations
- 2019Dynamic viscoelastic characterisation of human osteochondral tissuecitations
- 2018Formulation and viscoelasticity of mineralised hydrogels for use in bone-cartilage interfacial reconstructioncitations
- 2018The role of subchondral bone, and its histomorphology, on the dynamic viscoelasticity of cartilage, bone and osteochondral corescitations
- 2018Tailoring selective laser melting process for titanium drug-delivering implants with releasing micro-channelscitations
- 2016Adding functionality with additive manufacturing : fabrication of titanium-based antibiotic eluting implantscitations
Places of action
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article
Tailoring selective laser melting process for titanium drug-delivering implants with releasing micro-channels
Abstract
The use of drug-delivering implants can minimise implant failure due to infection through a controlled medication release into the surrounding tissues. In this study, selective laser melting (SLM) was employed to manufacture Ti-6Al-4 V samples, with internal reservoirs and releasing Micro-channels (MCs) to simulate what could be a drug-delivering orthopaedic or dental implant. Investigations were performed to optimise the design and SLM process parameters required to create the releasing MCs with minimum dimensional deviation to allow a controlled dosing of the drugs, while considering the process impact on the surface roughness and porosity of the builds. The build orientation, internal contour spacing, and laser process parameters were varied to assess their effect on the resolution of the MCs with diameters of ∼200–500 μm. It was found that, vertically oriented channels were found to have the least dimensional deviation from the target dimensions compared with horizontally-oriented or inclined channels. The dimensional deviation of the MCs was found in range of 220–427 μm, while the horizontal surface roughness (Ra) was in range of 1.46–11.46 μm and the vertical surface roughness (R<sub>a</sub>) was in range of 8.5–13.23 μm when applying energy density varying from of 27–200 J/mm3. It was found that, there was a clear correlation between the energy density with both dimensional deviation and horizontal surface roughness, while no correlation was found for the vertical’ surface roughness. The study identified the optimum conditions to manufacture drug-delivering metallic implants, creating hollow samples with releasing MCs equivalent diameter of ∼271 μm, horizontal surface roughness (R<sub>a</sub>) of 4.4 μm, vertical surface roughness of (R<sub>a</sub>) 9.2 μm, and build porosity of 1.4% using an internal contour of 150 μm and energy density of 35.7 J/mm<sup>3</sup>.