| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Shepherd, Duncan Et
University of Birmingham
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (24/24 displayed)
- 2024Frequency and time dependent viscoelastic characterization of pediatric porcine brain tissue in compressioncitations
- 2022Bio-Tribo-Acoustic Emissions: Condition Monitoring of a Simulated Joint Articulationcitations
- 2022Long-term in vitro corrosion behavior of Zn-3Ag and Zn-3Ag-0.5Mg alloys considered for biodegradable implant applicationscitations
- 2022Surface Free Energy Dominates the Biological Interactions of Postprocessed Additively Manufactured Ti-6Al-4Vcitations
- 2021Surface finish of additively manufactured metalscitations
- 2021Investigation of the compressive viscoelastic properties of brain tissue under time and frequency dependent loading conditionscitations
- 2020Dynamic mechanical characterization and viscoelastic modeling of bovine brain tissuecitations
- 2020A method for the assessment of the coefficient of friction of articular cartilage and a replacement biomaterialcitations
- 2019Frequency dependent viscoelastic properties of porcine brain tissuecitations
- 2018The role of subchondral bone, and its histomorphology, on the dynamic viscoelasticity of cartilage, bone and osteochondral corescitations
- 2018Tailoring selective laser melting process for titanium drug-delivering implants with releasing micro-channelscitations
- 2017Crack growth in medical-grade silicone and polyurethane ether elastomerscitations
- 2016Design of a Dynamic External Finger Fixatorcitations
- 2015Frequency dependent viscoelastic properties of porcine bladdercitations
- 2015The evolution of polymer wear debris from total disc arthroplastycitations
- 2015Variation in viscoelastic properties of bovine articular cartilage below, up to and above healthy gait-relevant loading frequenciescitations
- 2014Viscoelastic properties of bovine knee joint articular cartilage : dependency on thickness and loading frequencycitations
- 2013Abrasive Water Jet Cutting (AWJC) of Co-Cr-Mo alloy investment castings in the medical device industry
- 2011Viscoelastic properties of the intervertebral disc and the effect of nucleus pulposus removalcitations
- 2010Effect of accelerated aging on the viscoelastic properties of Elast-Eon (TM): A polyurethane with soft poly(dimethylsiloxane) and poly(hexamethylene oxide) segmentscitations
- 2009Viscoelastic properties of bovine articular cartilage attached to subchondral bone at high frequenciescitations
- 2009Frequency dependence of viscoelastic properties of medical grade siliconescitations
- 2005A new design concept for wrist arthroplastycitations
- 2004A comparison of the torsional performance of stainless steel and titanium alloy tibial intramedullary nails: a clinically relevant approach
Places of action
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article
Tailoring selective laser melting process for titanium drug-delivering implants with releasing micro-channels
Abstract
The use of drug-delivering implants can minimise implant failure due to infection through a controlled medication release into the surrounding tissues. In this study, selective laser melting (SLM) was employed to manufacture Ti-6Al-4 V samples, with internal reservoirs and releasing Micro-channels (MCs) to simulate what could be a drug-delivering orthopaedic or dental implant. Investigations were performed to optimise the design and SLM process parameters required to create the releasing MCs with minimum dimensional deviation to allow a controlled dosing of the drugs, while considering the process impact on the surface roughness and porosity of the builds. The build orientation, internal contour spacing, and laser process parameters were varied to assess their effect on the resolution of the MCs with diameters of ∼200–500 μm. It was found that, vertically oriented channels were found to have the least dimensional deviation from the target dimensions compared with horizontally-oriented or inclined channels. The dimensional deviation of the MCs was found in range of 220–427 μm, while the horizontal surface roughness (Ra) was in range of 1.46–11.46 μm and the vertical surface roughness (R<sub>a</sub>) was in range of 8.5–13.23 μm when applying energy density varying from of 27–200 J/mm3. It was found that, there was a clear correlation between the energy density with both dimensional deviation and horizontal surface roughness, while no correlation was found for the vertical’ surface roughness. The study identified the optimum conditions to manufacture drug-delivering metallic implants, creating hollow samples with releasing MCs equivalent diameter of ∼271 μm, horizontal surface roughness (R<sub>a</sub>) of 4.4 μm, vertical surface roughness of (R<sub>a</sub>) 9.2 μm, and build porosity of 1.4% using an internal contour of 150 μm and energy density of 35.7 J/mm<sup>3</sup>.