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Naji, M. |
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Motta, Antonella |
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Aletan, Dirar |
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Mohamed, Tarek |
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Ertürk, Emre |
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Taccardi, Nicola |
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Kononenko, Denys |
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Petrov, R. H. | Madrid |
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Alshaaer, Mazen | Brussels |
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Bih, L. |
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Casati, R. |
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Muller, Hermance |
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Kočí, Jan | Prague |
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Šuljagić, Marija |
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Kalteremidou, Kalliopi-Artemi | Brussels |
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Azam, Siraj |
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Ospanova, Alyiya |
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Blanpain, Bart |
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Ali, M. A. |
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Popa, V. |
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Rančić, M. |
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Ollier, Nadège |
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Azevedo, Nuno Monteiro |
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Landes, Michael |
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Rignanese, Gian-Marco |
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Gloter, Alexandre
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (27/27 displayed)
- 2024Polar discontinuity governs surface segregation and interface termination: A case study of LaInO$_3$/BaSnO$_3$citations
- 2024Origin of the Surface Magnetic Dead Layer in Rare‐Earth Titanates
- 2024Unraveling P‐Type and N‐Type Interfaces in Superconducting Infinite‐Layer Nickelate Thin Filmscitations
- 2024Polar discontinuity governs surface segregation and interface termination: A case study of LaIn O3/ BaSn O3
- 2024Toward Reliable Synthesis of Superconducting Infinite Layer Nickelate Thin Films by Topochemical Reductioncitations
- 2024Toward Reliable Synthesis of Superconducting Infinite Layer Nickelate Thin Films by Topochemical Reductioncitations
- 2024Valence-Ordered Thin-Film Nickelate with Tri-component Nickel Coordination Prepared by Topochemical Reductioncitations
- 2023Plasmonic Properties of SrVO Bulk and Nanostructurescitations
- 2023Mapping the complex evolution of ferroelastic/ferroelectric domain patterns in epitaxially strained PbTiO3 heterostructurescitations
- 2023Strontium-driven physiological to pathological transition of bone-like architecture: A dose-dependent investigationcitations
- 2023Synthesis of infinite-layer nickelates and influence of the capping-layer on magnetotransportcitations
- 2022Strain tuning of Néel temperature in YCrO 3 epitaxial thin filmscitations
- 2021Depth profile reconstruction of YCrO3 / CaMnO3 superlattices by near total reflection HAXPEScitations
- 2021Surface and bulk ferroelectric phase transition in super-tetragonal BiFeO 3 thin filmscitations
- 2020Evolution of structural and magnetic properties of multifunctional bismuth iron garnets upon Ca and Y dopingcitations
- 2020Role of point and line defects on the electronic structure of LaAlO3/SrTiO3 interfacescitations
- 2019Room Temperature Blocked Magnetic Nanoparticles Based on Ferrite Promoted by a Three-Step Thermal Decomposition Processcitations
- 2017In-situ determination of the kinetics and mechanisms of nickel adsorption by nanocrystalline vernaditecitations
- 2013Direct Evidence of Fe2+-Fe3+ Charge Ordering in the ferrimagnetic Hematite-Ilmenite Fe1.35Ti0.65O3 -d Thin Filmscitations
- 2011Nanoscale chemical and structural study of Co-based FEBID structures by STEM-EELS and HRTEM
- 2011Nanoscale chemical and structural study of Co- based FEBID structures by STEM-EELS and HRTEMcitations
- 2010Synthesis and Cathodoluminescence of Undoped and Cr^3^+-Doped Sodium Titanate Nanotubes and Nanoribbonscitations
- 2010Synthesis and cathodoluminescence of undoped and Cr^(3+)-doped Sodium Titanate nanotubes and nanoribbonscitations
- 2009Insights into the mechanism of the gas-phase purification of HiPco SWNTs through a comprehensive multi-technique studycitations
- 2009Segregation tendency in layered aluminum-substituted lithium nickel oxidescitations
- 2008Geometric and electronic structure of alpha-oxygen sites in Mn-ZSM-5 zeolitescitations
- 2008Geometric and electronic structure of alpha-oxygen sites in Mn-ZSM-5 zeolites
Places of action
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article
Strontium-driven physiological to pathological transition of bone-like architecture: A dose-dependent investigation
Abstract
Whilst strontium (Sr 2 +) is widely investigated for treating osteoporosis, it is also related to mineralization disorders such as rickets and osteomalacia. In order to clarify the physiological and pathological effects of Sr 2 + on bone biomineralization , we performed a dose-dependent investigation in bone components using a 3D scaffold that displays the hallmark features of bone tissue in terms of composition (osteoblast, collagen, carbonated apatite) and architecture (mineralized collagen fibrils hierarchically assembled into a twisted plywood geometry). As the level of Sr 2 + is increased from physiological-like to excess, both the mineral and the collagen fibrils assembly are destabilized, leading to a drop in the Young modulus, with strong implications on pre-osteoblastic cell proliferation. Furthermore, the microstructural and mechanical changes reported here correlate with that observed in bone-weakening disorders induced by Sr 2 + accumulation, which may clarify the paradoxical effects of Sr 2 + in bone mineralization. More generally, our results provide physicochemical insights into the possible effects of inorganic ions on the assembly of bone extracellular matrix and may contribute to the design of safer therapies for treating osteoporosis.