| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Nassif, Nadine
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (8/8 displayed)
- 2024Acidic Osteoid Templates the Plywood Structure of Bone Tissue.citations
- 2024Hierarchical Collagen/Apatite Co-assembly for Injection of Mineralized Fibrillar Tissue Analogues
- 2024Hierarchical collagen/apatite co-assembly for injection of mineralized fibrillar tissue analogues
- 2023Acidic Osteoid Templates the Plywood Structure of Bone Tissuecitations
- 2023Strontium-driven physiological to pathological transition of bone-like architecture: A dose-dependent investigationcitations
- 2022Inorganic phosphate in growing calcium carbonate abalone shell suggests a shared mineral ancestral precursorcitations
- 2020Chemical Heterogeneities within the Disordered Mineral domains of Aragonite Platelets in nacre from the European Abalone Haliotis tuberculatacitations
- 2018Interplay between Calcite, Amorphous Calcium Carbonate, and Intracrystalline Organics in Sea Urchin Skeletal Elementscitations
Places of action
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article
Strontium-driven physiological to pathological transition of bone-like architecture: A dose-dependent investigation
Abstract
Whilst strontium (Sr 2 +) is widely investigated for treating osteoporosis, it is also related to mineralization disorders such as rickets and osteomalacia. In order to clarify the physiological and pathological effects of Sr 2 + on bone biomineralization , we performed a dose-dependent investigation in bone components using a 3D scaffold that displays the hallmark features of bone tissue in terms of composition (osteoblast, collagen, carbonated apatite) and architecture (mineralized collagen fibrils hierarchically assembled into a twisted plywood geometry). As the level of Sr 2 + is increased from physiological-like to excess, both the mineral and the collagen fibrils assembly are destabilized, leading to a drop in the Young modulus, with strong implications on pre-osteoblastic cell proliferation. Furthermore, the microstructural and mechanical changes reported here correlate with that observed in bone-weakening disorders induced by Sr 2 + accumulation, which may clarify the paradoxical effects of Sr 2 + in bone mineralization. More generally, our results provide physicochemical insights into the possible effects of inorganic ions on the assembly of bone extracellular matrix and may contribute to the design of safer therapies for treating osteoporosis.