| People | Locations | Statistics |
|---|---|---|
| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Ito, Keita
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (13/13 displayed)
- 2023Warp-knitted fabric structures for a novel biomimetic artificial intervertebral disc for the cervical spine
- 2022Surface texture analysis of different focal knee resurfacing implants after 6 and 12 months in vivo in a goat modelcitations
- 2022Surface texture analysis of different focal knee resurfacing implants after 6 and 12 months in vivo in a goat modelcitations
- 2022A bovine nucleus pulposus explant culture modelcitations
- 2021Proteoglycan 4 reduces friction more than other synovial fluid components for both cartilage-cartilage and cartilage-metal articulationcitations
- 2020Accuracy of beam theory for estimating bone tissue modulus and yield stress from 3-point bending tests on rat femoracitations
- 2020T2* mapping in an equine articular groove model - visualizing changes in collagen orientationcitations
- 2019Bi-layered micro-fibre reinforced hydrogels for articular cartilage regenerationcitations
- 2019Resorption of the calcium phosphate layer on S53P4 bioactive glass by osteoclastscitations
- 2017Magnetic domain walls in nanostrips of single-crystalline Fe4N thin films with fourfold in-plane magnetic anisotropycitations
- 2016Mechanical properties of bioactive glass putty formulations
- 2016Silk fibroin as biomaterial for bone tissue engineeringcitations
- 2013A new model to study healing of a complex femur fracture with concurrent soft tissue injury in sheepcitations
Places of action
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article
Bi-layered micro-fibre reinforced hydrogels for articular cartilage regeneration
Abstract
Articular cartilage has limited capacity for regeneration and when damaged cannot be repaired with currently available metallic or synthetic implants. We aim to bioengineer a microfibre-reinforced hydrogel that can capture the zonal depth-dependent mechanical properties of native cartilage, and simultaneously support neo-cartilage formation. With this goal, a sophisticated bi-layered microfibre architecture, combining a densely distributed crossed fibre mat (superficial tangential zone, STZ) and a uniform box structure (middle and deep zone, MDZ), was successfully manufactured via melt electrospinning and combined with a gelatin–methacrylamide hydrogel. The inclusion of a thin STZ layer greatly increased the composite construct's peak modulus under both incongruent (3.2-fold) and congruent (2.1-fold) loading, as compared to hydrogels reinforced with only a uniform MDZ structure. Notably, the stress relaxation response of the bi-layered composite construct was comparable to the tested native cartilage tissue. Furthermore, similar production of sulphated glycosaminoglycans and collagen II was observed for the novel composite constructs cultured under mechanical conditioning w/o TGF-ß1 supplementation and in static conditions w/TGF-ß1 supplementation, which confirmed the capability of the novel composite construct to support neo-cartilage formation upon mechanical stimulation. To conclude, these results are an important step towards the design and manufacture of biomechanically competent implants for cartilage regeneration. Statement of Significance: Damage to articular cartilage results in severe pain and joint disfunction that cannot be treated with currently available implants. This study presents a sophisticated bioengineered bi-layered fibre reinforced cell-laden hydrogel that can approximate the functional mechanical properties of native cartilage. For the first time, the importance of incorporating a viable superficial tangential zone (STZ) – like structure to improve the load-bearing properties of ...