| People | Locations | Statistics |
|---|---|---|
| Naji, M. |
| |
| Motta, Antonella |
| |
| Aletan, Dirar |
| |
| Mohamed, Tarek |
| |
| Ertürk, Emre |
| |
| Taccardi, Nicola |
| |
| Kononenko, Denys |
| |
| Petrov, R. H. | Madrid |
|
| Alshaaer, Mazen | Brussels |
|
| Bih, L. |
| |
| Casati, R. |
| |
| Muller, Hermance |
| |
| Kočí, Jan | Prague |
|
| Šuljagić, Marija |
| |
| Kalteremidou, Kalliopi-Artemi | Brussels |
|
| Azam, Siraj |
| |
| Ospanova, Alyiya |
| |
| Blanpain, Bart |
| |
| Ali, M. A. |
| |
| Popa, V. |
| |
| Rančić, M. |
| |
| Ollier, Nadège |
| |
| Azevedo, Nuno Monteiro |
| |
| Landes, Michael |
| |
| Rignanese, Gian-Marco |
|
Kennedy, Andrew R.
Lancaster University
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (16/16 displayed)
- 2020Compression moulding and injection over moulding of porous PEEK componentscitations
- 2020Generation of graded porous structures by control of process parameters in the selective laser melting of a fixed ratio salt-metal feedstockcitations
- 2020Measurement and modelling of the elastic defection of novel metal syntactic foam composite sandwich structures in 3-point bendingcitations
- 2019Development of metal matrix composites by direct energy deposition of ‘satellited’ powderscitations
- 2019In vitro cellular testing of strontium/calcium substituted phosphate glass discs and microspheres shows potential for bone regenerationcitations
- 2018Pressure-assisted infiltration of molten metals into non-rigid, porous carbon fibre structurescitations
- 2018Modelling and optimisation of sound absorption in replicated microcellular metalscitations
- 2018Porous calcium phosphate glass microspheres for orthobiologic applicationscitations
- 2018Salt-metal feedstocks for the creation of stochastic cellular structures with controlled relative density by powder bed fabricationcitations
- 2017A water-soluble core material for manufacturing hollow composite sectionscitations
- 2016Effect of solidification rate on pore connectivity of aluminium foams and its consequences on mechanical propertiescitations
- 2015Porous titanium manufactured by a novel powder tapping method using spherical salt bead space holders: characterisation and mechanical propertiescitations
- 2015Porous poly-ether ether ketone (PEEK) manufactured by a novel powder route using near-spherical salt bead porogenscitations
- 2015Porous poly-ether ether ketone (PEEK) manufactured by a novel powder route using near-spherical salt bead porogens : characterisation and mechanical properties
- 2015A study of an improved cutting mechanism of composite materials using novel design of diamond micro-core drillscitations
- 2015Discrete element modelling of flexible fibre packingcitations
Places of action
| Organizations | Location | People |
|---|
article
Porous calcium phosphate glass microspheres for orthobiologic applications
Abstract
Orthobiologics is a rapidly advancing field utilising cell-based therapies and biomaterials to enable the body to repair and regenerate musculoskeletal tissues. This paper reports on a cost-effective flame spheroidisation process for production of novel porous glass microspheres from calcium phosphate-based glasses to encapsulate and deliver stem cells. Careful selection of the glass and pore-forming agent, along with a manufacturing method with the required processing window enabled the production of porous glass microspheres via a single-stage manufacturing process. The morphological and physical characterisation revealed porous microspheres with tailored surface and interconnected porosity (up to 76 ± 5%) with average pore size of 55 ± 8 µm and surface areas ranging from 0.34 to 0.9 m2 g−1. Furthermore, simple alteration of the processing parameters produced microspheres with alternate unique morphologies, such as with solid cores and surface porosity only. The tuneable porosity enabled control over their surface area, degradation profiles and hence ion release rates. Furthermore, cytocompatibility of the microspheres was assessed using human mesenchymal stem cells via direct cell culture experiments and analysis confirmed that they had migrated to within the centre of the microspheres. The novel microspheres developed have huge potential for tissue engineering and regenerative medicine applications.<br/><br/>Statement of Significance<br/>This manuscript highlights a simple cost-effective one-step process for manufacturing porous calcium phosphate-based glass microspheres with varying control over surface pores and fully interconnected porosity via a flame spheroidisation process. Moreover, a simple alteration of the processing parameters can produce microspheres which have a solid core with surface pores only. The tuneable porosity enabled control over their surface area, degradation profiles and hence ion release rates. The paper also shows that stem cells not only attach and proliferate but more importantly migrate to within the core of the porous microspheres, highlighting applications for bone tissue engineering and regenerative medicine.