| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Derby, Brian
University of Manchester
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (45/45 displayed)
- 2021Influence of Twin Boundaries and Sample Dimensions on the Mechanical Behavior of Ag Nanowires
- 2020Oil-in-water separation with graphene-based nanocomposite membranes for produced water treatmentcitations
- 2020Patterned, morphing composites via maskless photo-click lithographycitations
- 2020Nanoindentation of Molecular Crystals: Lessons Learned from Aspirincitations
- 2020Direct 3D Printing of Graphene Using Capillary Suspensionscitations
- 2020Size Effects on Strength and Plasticity of Ferrite and Austenite Pillars in a Duplex Stainless Steel
- 2020Tiled Monolayer Films of 2D Molybdenum Disulphide Nanoflakes Assembled at Liquid/Liquid Interfacescitations
- 2019The size dependent strength of Fe, Nb and V micropillars at room and low temperaturecitations
- 2017Solution Processing of Two-Dimensional Black Phosphoruscitations
- 2017Graphene-reinforced chitosan/PDMS morphing composites
- 2017Stabilization of a T -ZrO2 polymorph in a glassy SiO2 matrix at elevated temperatures accomplished by ceria additionscitations
- 2017Tetragonal to cubic transformation of SiO2 stabilized ZrO2 polymorph through dysprosium substitutionscitations
- 2016Frequency-modulated atomic force microscopy localises viscoelastic remodelling in the ageing sheep aortacitations
- 2016A pilot study of scanning acoustic microscopy as a tool for measuring arterial stiffness in aortic biopsiescitations
- 2015Biomechanical Changes of Collagen Cross-Linking on Human Keratoconic Corneas Using Scanning Acoustic Microscopy.citations
- 2015Mechanical properties of porous ceramic scaffolds: Influence of internal dimensionscitations
- 2015Mechanical properties of porous ceramic scaffolds: Influence of internal dimensions:Influence of Internal Dimensionscitations
- 2014Biomechanical changes after repeated collagen cross-linking on human corneas assessed in vitro using scanning acoustic microscopycitations
- 2014Combining AFM and Acoustic Probes to Reveal Changes in the Elastic Stiffness Tensor of Living Cellscitations
- 2014Growth differentiation factor 6 and transforming growth factor-beta differentially mediate mesenchymal stem cell differentiation, composition, and micromechanical properties of nucleus pulposus constructscitations
- 2014Localized micro- and nano-scale remodelling in the diabetic aortacitations
- 2013Biomechanical properties of human corneas following low- and high-intensity collagen cross-linking determined with scanning acoustic microscopycitations
- 2013Scanning acoustic microscopy for mapping the microelastic properties of human corneal tissuecitations
- 2012Multi-layer phase analysis: Quantifying the elastic properties of soft tissues and live cells with ultra-high-frequency scanning acoustic microscopycitations
- 2012Gel-cast glass-ceramic tissue scaffolds of controlled architecture produced via stereolithography of mouldscitations
- 2011The mechanical properties of float glass surfaces measured by nanoindentation and acoustic microscopycitations
- 2011Quantifying micro-mechanical properties of soft biological tissues with scanning acoustic microscopycitations
- 2009Limits to feature size and resolution in ink jet printingcitations
- 2008Residual stress distributions around indentations and scratches in polycrystalline Al2O3 and Al2O3/SiC nanocomposites measured using fluorescence probescitations
- 2008Nanoindentation of histological specimens using an extension of the Oliver and Pharr methodcitations
- 2007Correlations for single-crystal elastic constants of compound semiconductors and their representation in isomechanical groupscitations
- 2007Characterization of photo-reduced silver organometallic salt deposited by inkjet printing
- 2005Viscosity and acoustic behavior of ceramic suspensions optimized for phase-change ink-jet printingcitations
- 2004Modelling of R-curve behaviour in ceramic-metal laminatescitations
- 2004Thermal stress induced microcracking in alumina-20% SiCp compositescitations
- 2004In Situ Characterization of Interfaces between Liquid Tin-Vanadium Alloys and Alumina by Neutron Reflection Spectroscopycitations
- 2003Characterisation of void and reinforcement distributions in a metal matrix composite by X-ray edge-contrast microtomographycitations
- 2003Multilayer nitride coatings by closed field unbalanced magnetron sputter ion platingcitations
- 2002Direct ink jet printing of alumina components
- 2001Residual stress and subsurface damage in machined alumina and alumina/silicon carbide nanocomposite ceramicscitations
- 2001Accurate determination of Young's modulus and Poisson's ratio of thin films by a combination of acoustic microscopy and nanoindentationcitations
- 2001Detection of particle damage event by acoustic emission during tensile straining of SiC particle reinforced aluminum alloy composites
- 2001Direct Ink Jet Printing of Alumina Componentscitations
- 2000Matrix flow and densification during the consolidation of matrix coated fibrescitations
- 2000Freeform Fabrication of Ceramics by Hot-Melt Ink-Jet Printingcitations
Places of action
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article
Localized micro- and nano-scale remodelling in the diabetic aorta
Abstract
Diabetes is strongly associated with cardiovascular disease, but the mechanisms, structural and biomechanical consequences of aberrant blood vessel remodelling remain poorly defined. Using an experimental (streptozotocin, STZ) rat model of diabetes, we hypothesized that diabetes enhances extracellular protease activity in the aorta and induces morphological, compositional and localized micromechanical tissue remodelling. We found that the medial aortic layer underwent significant thickening in diabetic animals but without significant changes in collagen or elastin (abundance). Scanning acoustic microscopy demonstrated that such tissue remodelling was associated with a significant decrease in acoustic wave speed (an indicator of reduced material stiffness) in the inter-lamellar spaces of the vessel wall. This index of decreased stiffness was also linked to increased extracellular protease activity (assessed by semi-quantitative in situ gelatin zymography). Such a proteolytically active environment may affect the macromolecular structure of long-lived extracellular matrix molecules. To test this hypothesis, we also characterized the effects of diabetes on the ultrastructure of an important elastic fibre component: the fibrillin microfibril. Using size exclusion chromatography and atomic force microscopy, we isolated and imaged microfibrils from both healthy and diabetic aortas. Microfibrils derived from diabetic tissues were fragmented, morphologically disrupted and weakened (as assessed following molecular combing). These structural and functional abnormalities were not replicated by in vitro glycation. Our data suggest that proteolysis may be a key driver of localized mechanical change in the inter-lamellar space of diabetic rat aortas and that structural proteins (such as fibrillin microfbrils) may be biomarkers of diabetes induced damage. © 2014 Acta Materialia Inc.