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Naji, M. |
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Motta, Antonella |
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Aletan, Dirar |
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Mohamed, Tarek |
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Ertürk, Emre |
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Taccardi, Nicola |
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Kononenko, Denys |
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Petrov, R. H. | Madrid |
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Alshaaer, Mazen | Brussels |
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Bih, L. |
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Casati, R. |
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Muller, Hermance |
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Kočí, Jan | Prague |
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Šuljagić, Marija |
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Kalteremidou, Kalliopi-Artemi | Brussels |
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Azam, Siraj |
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Ospanova, Alyiya |
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Blanpain, Bart |
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Ali, M. A. |
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Popa, V. |
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Rančić, M. |
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Ollier, Nadège |
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Azevedo, Nuno Monteiro |
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Landes, Michael |
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Rignanese, Gian-Marco |
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Sun, L.
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (16/16 displayed)
- 2021Effect of texture and mechanical anisotropy on flow behaviour in Ti-6Al-4V alloy under superplastic forming conditionscitations
- 2021Unveiling Planar Defects in Hexagonal Group IV Materialscitations
- 2020Chlorides entrapment capability of various in-situ grown NiAl-LDHs: Structural and corrosion resistance propertiescitations
- 2018A novel ultra-high strength maraging steel with balanced ductility and creep resistance achieved by nanoscale β-NiAl and Laves phase precipitatescitations
- 2018The effect of thermomechanical controlled processing on recrystallisation and subsequent deformation-induced ferrite transformation textures in microalloyed steels
- 2017Precipitation in a novel maraging steel F1E:A study of austenitization and aging using small angle neutron scatteringcitations
- 2017A SANS and APT study of precipitate evolution and strengthening in a maraging steelcitations
- 2017A SANS and APT study of precipitate evolution and strengthening in a maraging steelcitations
- 2017Precipitation in a novel maraging steel F1Ecitations
- 2017Is iron unique in promoting electrical conductivity in MOFs?citations
- 2016Insights into microstructural interfaces in aerospace alloys characterised by atom probe tomographycitations
- 2012Aligned silk-based 3-D architectures for contact guidance in tissue engineeringcitations
- 2008Ion irradiation of carbon nanotubes encapsulating cobalt crystalscitations
- 2008Designing silk-based 3D architectures with controlled lamellar morphology
- 2007Crystallization and preliminary crystallographic analysis of an esterese with a novel domein from the hyperthermophile Thermotoga maritimacitations
- 2007Crystallization and preliminary crystallographic analysis of an esterese with a novel domein from the hyperthermophile Thermotoga maritimacitations
Places of action
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article
Aligned silk-based 3-D architectures for contact guidance in tissue engineering
Abstract
<p>An important challenge in the biomaterials field is to mimic the structure of functional tissues via cell and extracellular matrix (ECM) alignment and anisotropy. Toward this goal, silk-based scaffolds resembling bone lamellar structure were developed using a freeze-drying technique. The structure could be controlled directly by solute concentration and freezing parameters, resulting in lamellar scaffolds with regular morphology. Different post-treatments, such as methanol, water annealing and steam sterilization, were investigated to induce water stability. The resulting structures exhibited significant differences in terms of morphological integrity, structure and mechanical properties. The lamellar thicknesses were ∼2.6 μm for the methanol-treated scaffolds and ∼5.8 μm for water-annealed. These values are in the range of those reported for human lamellar bone. Human bone marrow-derived mesenchymal stem cells (hMSC) were seeded on these silk fibroin lamellar scaffolds and grown under osteogenic conditions to assess the effect of the microstructure on cell behavior. Collagen in the newly deposited ECM was found aligned along the lamellar architectures. In the case of methanol-treated lamellar structures, the hMSC were able to migrate into the interior of the scaffolds, producing a multilamellar hybrid construct. The present morphology constitutes a useful pattern onto which hMSC cells attach and proliferate for guided formation of a highly oriented extracellular matrix.</p>