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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Casati, R. |
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| Kočí, Jan | Prague |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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Bagchi, Arka
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article
Synthesis, spectroscopy and structural elucidation of two new CoII and NiII complexes of pyrazole derived heterocyclic Schiff base ligand as potential anticancer and photocatalytic agents
Abstract
Two new complexes I and II of general composition, [ML<sub>3</sub>]X<sub>2</sub>.nH<sub>2</sub>O (where, M = Co<sup style="box-sizing: inherit; color: rgb(34, 34, 34); font-family: Merriweather, serif;">II</sup> and Ni<sup style="box-sizing: inherit; color: rgb(34, 34, 34); font-family: Merriweather, serif;">II</sup> for I and II, respectively, L = MPAFA, X = Br and n = 2) were synthesized from a pyrazolyl Schiff base ligand, MPAFA (L). I and II were characterised through several physico-chemical and spectroscopic techniques, viz., C, H, N analyses, estimation of metal contents, conductance and magnetic susceptibility measurements, IR, electronic and fluorescence spectral studies. Both the reported coordination complexes were cationic in nature and behaved as 1:2 electrolytes. According to IR spectra, each of the MPAFA molecule coordinated to the metal centres via the azomethine nitrogen and the pyrazolyl tertiary nitrogen atoms. Single crystal X-ray diffraction studies of I and II had established a N6 donor set with a distorted octahedral structure for both the cases. Both the complexes exhibited some non-covalent interactions, like π…π stacking, H-bonding contacts etc. L, I and II had also been found to possess fluorescence property. Anticancer activities of L, I and II had been investigated and it was found that both the complexes I and II were stronger cytotoxic agents against the breast cancer cell line MCF7 than the primary ligand system; while all of them (L, I and II) were less toxic against a non-cancerous cell line HEK293. All the compounds had shown potential photocatalytic activity in degrading methylene-blue (MB).