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Devi, S. S.
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article
Bio-corrosion and Cytotoxicity Studies on Novel Zr<SUB>55</SUB>Co<SUB>30</SUB>Ti<SUB>15</SUB> and Cu<SUB>60</SUB>Zr<SUB>20</SUB>Ti<SUB>20</SUB> Metallic Glasses
Abstract
Metallic glasses are a potential and compatible implant candidate for biomedical applications. In the present investigation, a comparative study between novel Zr<SUB>55</SUB>Co<SUB>30</SUB>Ti<SUB>15</SUB> and Cu<SUB>60</SUB>Zr<SUB>20</SUB>Ti<SUB>20</SUB> metallic glasses is carried out to evaluate in vitro biocompatibility using simulated body fluids. The bio-corrosion behavior of Zr- and Cu-based metallic glasses in different types of artificial body fluids such as artificial saliva solution, phosphate-buffered saline solution, artificial blood plasma solution, and Hank's balanced saline solution is evaluated using potentiodynamic polarization studies at a constant body temperature of 310.15 K (37 °C). Surface morphology of samples after bio-corrosion experiments was observed by scanning electron microscopy. In vitro cytotoxicity test on glassy alloys were performed using human osteosarcoma cell line as per 10993-5 guidelines from International Organization for Standardization. The comparative study between Zr- and Cu-based glassy alloys provides vital information about the effect of elemental composition on biocompatibility of metallic glasses.