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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Montenegro, Mcbsm
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (7/7 displayed)
- 2020In vitro assessment of polyethylene glycol and polyvinylpyrrolidone as hydrophilic additives on bioseparation by polysulfone membranescitations
- 2017Synthesis of distinctly thiol-capped CdTe quantum dots under microwave heating: multivariate optimization and characterizationcitations
- 2011Novel LTCC-potentiometric microfluidic device for biparametric analysis of organic compounds carrying plastic antibodies as ionophores: Application to sulfamethoxazole and trimethoprimcitations
- 2009Modeling, Structural, and Spectroscopic Studies of Lanthanide-Organic Frameworkscitations
- 2006Extraction and recovery of chromium from electroplating sludgecitations
- 2003Monosegemented flow potentiometric titration for the determination of chloride in milk and winecitations
- 2001Sequential injection analysis of captopril based on colorimetric and potentiometric detectioncitations
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article
In vitro assessment of polyethylene glycol and polyvinylpyrrolidone as hydrophilic additives on bioseparation by polysulfone membranes
Abstract
Considering the continuous increment of morbidity in patients with renal disease, the improvement of polymeric membranes characteristics for haemodialysis is a challenging issue. The efficient removal of middle size uremic toxins, as well as biocompatibility is crucial characteristics to ameliorate chronic kidney disease patients' outcomes. In this study, polysulfone membranes with different hydrophilic additives, molecular weight and concentrations were prepared by spin coating method, followed by phase inversion via immersion precipitation. The removal of urea, lysozyme and bovine serum albumin was studied using a miniaturized flow system, mimicking haemodialysis conditions. The optimal composition was 15.0 wt% of polysulfone and 2.5 wt% of polyvinylpyrrolidone K30. This selected membrane was fully permeable for urea, showed up to 50% rejection of lysozyme and very high rejection of albumin. The additive PVP K30 played important role in the improvement of porosity, without compromising the mechanical strength of the membrane. The biocompatibility of membrane was evaluated by material-induced haemolysis and platelet activation tests. The platelet activation and haemolysis were negligible, compared to other biocompatible materials. These results confirmed the haemocompatibility of the optimized membrane. Therefore, the membrane is not expected to modulate the biological response, when used for the haemodialysis treatment.