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Naji, M. |
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Motta, Antonella |
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Aletan, Dirar |
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Mohamed, Tarek |
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Ertürk, Emre |
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Taccardi, Nicola |
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Kononenko, Denys |
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Petrov, R. H. | Madrid |
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Alshaaer, Mazen | Brussels |
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Bih, L. |
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Casati, R. |
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Muller, Hermance |
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Kočí, Jan | Prague |
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Šuljagić, Marija |
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Kalteremidou, Kalliopi-Artemi | Brussels |
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Azam, Siraj |
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Ospanova, Alyiya |
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Blanpain, Bart |
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Ali, M. A. |
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Popa, V. |
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Rančić, M. |
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Ollier, Nadège |
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Azevedo, Nuno Monteiro |
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Landes, Michael |
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Rignanese, Gian-Marco |
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Neves, Ic
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (12/12 displayed)
- 2021Performance of self-cleaning cotton textiles coated with TiO2, TiO2-SiO2 and TiO2-SiO2-HY in removing Rhodamine B and Reactive Red 120 dyes from aqueous solutionscitations
- 2020Binuclear furanyl-azine metal complexes encapsulated in NaY zeolite as efficiently heterogeneous catalysts for phenol hydroxylationcitations
- 2019Photocatalytic performance of N-doped TiO(2)nano-SiO2-HY nanocomposites immobilized over cotton fabricscitations
- 2015Preparation and assessment of antimicrobial properties of bimetallic materials based on NaY zeolitecitations
- 2013Nanocomposites of poly(epsilon-caprolactone) doped with titanium speciescitations
- 2011Encapsulation of alpha-cyano-4-hydroxycinnamic acid into a NaY zeolitecitations
- 2011Stability of nanocomposites of poly(epsilon-caprolactone) with tungsten trioxidecitations
- 2010Enhancement of the Dielectric Constant and Thermal Properties of alpha-Poly(vinylidene fluoride)/Zeolite Nanocompositescitations
- 2009Redox properties of (1-(2-pyridylazo)-2-naphthol)copper(II) encapsulated in Y Zeolitecitations
- 2008Immobilization of Fe(III) complexes of pyridazine derivatives prepared from biosorbents supported on zeolitescitations
- 2008Organic-inorganic hybrid matrix doped with alkenyldiazenido complexes of molybdenumcitations
- 2004Synthesis and immobilization of molybdenum complexes in a pillared layered claycitations
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article
Encapsulation of alpha-cyano-4-hydroxycinnamic acid into a NaY zeolite
Abstract
The faujasite zeolite structure was studied to investigate its suitability for development of new drug delivery systems (DDS). The sodium form (NaY) of the zeolite was used for encapsulation of alpha-cyano-4-hydroxycinnamic acid (CHC), an experimental anticancer drug used in colorectal cancer therapy. The DDS was prepared by diffusion in liquid phase of CHC as a guest in the void space of the host zeolite structure at pH 7.0. The molecular integrity of CHC in the encapsulation process was evaluated by proton nuclear magnetic resonance spectroscopy ((1)H NMR) and Ultraviolet-Visible spectroscopy (UV-Vis). The new drug delivery system, CHC@NaY, was characterized by Fourier transform infrared spectroscopy and UV-Vis, chemical analysis, powder X-ray diffraction, and Scanning electron microscopy. Analysis of the data of the drug alone and encapsulated in NaY show that CHC and the zeolite framework preserved their original structure. The effect of the zeolite and DDS on HCT-15 human colon carcinoma cell line viability was evaluated. The encapsulation of CHC significantly increased its potency.