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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Roig, Anna
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (5/5 displayed)
- 2024Cellulose-in-cellulose 3D-printed bioaerogels for bone tissue engineeringcitations
- 2019Solar Harvesting: a Unique Opportunity for Organic Thermoelectrics?citations
- 2011Nanocomposites combining conducting and superparamagnetic components prepared via an organogelcitations
- 2004Ultraporous Single Phase Iron Oxide-Silica Nanostructured Aerogels from Ferrous Precursorscitations
- 2003Silica aerogel-iron oxide nanocomposites: Recoverable catalysts in conjugate additions and in the Biginelli reactioncitations
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article
Cellulose-in-cellulose 3D-printed bioaerogels for bone tissue engineering
Abstract
<jats:title>Abstract</jats:title><jats:p>Nanostructured scaffolds based on cellulose with advanced performances and personalized morphologies for bone tissue engineering are under technological development. 3D-printing and supercritical carbon dioxide (scCO<jats:sub>2</jats:sub>) technologies are innovative processing strategies that, when combined, allow the precise fabrication of highly porous aerogel scaffolds. Novel sterile cellulose-in-cellulose aerogels decorated with superparamagnetic iron oxide nanoparticles (SPIONs) are synthesized in this work by an integrated technological platform based on 3D-printing and scCO<jats:sub>2</jats:sub>. Methylcellulose (MC) and bacterial nanocellulose (BC) are two versatile cellulosic polysaccharides with remarkable physicochemical and biological performances, whereas SPIONs are commonly used to functionalize biomaterials aimed at tissue engineering. Aerogels with hierarchical porosity and high structural resolution were obtained according to nitrogen adsorption–desorption analysis, confocal, scanning and transmission microscopies (SEM and TEM). The magnetic properties of SPIONs-doped aerogels confirmed the correct functionalization of the nanostructures. Finally, NIH/3T3 fibroblast cell viability, hemocompatibility with human blood and safety tests (<jats:italic>in ovo</jats:italic> with HET-CAM and in vivo with <jats:italic>Artemia salina</jats:italic>) indicate the biocompatibility of the cellulose-in-cellulose aerogels.</jats:p><jats:p><jats:bold>Graphical abstract</jats:bold></jats:p>