• Kalff, Jörg C.
• Henn, Jonas
• Schmid, Matthias
• Buness, Andreas
• Matthaei, Hanno

Abstract

<jats:title>Abstract </jats:title><jats:sec><jats:title>Purpose</jats:title><jats:p>An indication for surgical therapy includes balancing benefits against risk, which remains a key task in all surgical disciplines. Decisions are oftentimes based on clinical experience while guidelines lack evidence-based background. Various medical fields capitalized the application of machine learning (ML), and preliminary research suggests promising implications in surgeons’ workflow. Hence, we evaluated ML’s contemporary and possible future role in clinical decision-making (CDM) focusing on abdominal surgery.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Using the PICO framework, relevant keywords and research questions were identified. Following the PRISMA guidelines, a systemic search strategy in the PubMed database was conducted. Results were filtered by distinct criteria and selected articles were manually full text reviewed.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Literature review revealed 4,396 articles, of which 47 matched the search criteria. The mean number of patients included was 55,843. A total of eight distinct ML techniques were evaluated whereas AUROC was applied by most authors for comparing ML predictions vs. conventional CDM routines. Most authors (<jats:italic>N</jats:italic> = 30/47, 63.8%) stated ML’s superiority in the prediction of benefits and risks of surgery. The identification of highly relevant parameters to be integrated into algorithms allowing a more precise prognosis was emphasized as the main advantage of ML in CDM.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>A potential value of ML for surgical decision-making was demonstrated in several scientific articles. However, the low number of publications with only few collaborative studies between surgeons and computer scientists underpins the early phase of this highly promising field. Interdisciplinary research initiatives combining existing clinical datasets and emerging techniques of data processing may likely improve CDM in abdominal surgery in the future.</jats:p></jats:sec>

Topics

• phase
• size-exclusion chromatography
• machine learning